Introduction to the T-Cell Lymphomas
The human skin contains a vast array of T cells, including cytotoxic, helper, memory, and regulatory subsets. Each of these cell types has different functional, proliferative, and migratory capacities. The diversity of cutaneous T-cell lymphomas (CTCL) reflects the multiplicity of T-cell subsets [1, 2]. The WHO/EORTC classification recognizes 15 cutaneous lymphomas, 10 of which are T-cell lymphomas. Their incidence and various organizational schemas for understanding CTCL are offered in this chapter. Each of the lymphomas is addressed individually in subsequent chapters.
KeywordsCutaneous T-cell lymphomas T cell Adult T-cell leukemia/lymphoma CD8+ aggressive epidermotropic cutaneous T-cell lymphoma Extranodal NK/T-cell lymphoma Mycosis fungoides Primary cutaneous anaplastic large cell lymphoma Primary cutaneous gamma/delta T-cell lymphoma Primary cutaneous small-medium pleomorphic T-cell lymphoma Sézary syndrome