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Introduction to the T-Cell Lymphomas

  • Amrita Goyal
  • Joi B. Carter
  • Lyn McDivitt DuncanEmail author

Abstract

The human skin contains a vast array of T cells, including cytotoxic, helper, memory, and regulatory subsets. Each of these cell types has different functional, proliferative, and migratory capacities. The diversity of cutaneous T-cell lymphomas (CTCL) reflects the multiplicity of T-cell subsets [1, 2]. The WHO/EORTC classification recognizes 15 cutaneous lymphomas, 10 of which are T-cell lymphomas. Their incidence and various organizational schemas for understanding CTCL are offered in this chapter. Each of the lymphomas is addressed individually in subsequent chapters.

Keywords

Cutaneous T-cell lymphomas T cell Adult T-cell leukemia/lymphoma CD8+ aggressive epidermotropic cutaneous T-cell lymphoma Extranodal NK/T-cell lymphoma Mycosis fungoides Primary cutaneous anaplastic large cell lymphoma Primary cutaneous gamma/delta T-cell lymphoma Primary cutaneous small-medium pleomorphic T-cell lymphoma Sézary syndrome 

References

  1. 1.
    Clark R. Regulation gone wrong: a subset of Sézary patients have malignant regulatory T cells. J Invest Dermatol. 2009;129:2747–50.PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Clark R. Skin-resident T, cells: the ups and downs of on site immunity. J Invest Dermatol. 2010;130:362–70.PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768–85.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amrita Goyal
    • 1
  • Joi B. Carter
    • 2
  • Lyn McDivitt Duncan
    • 3
    Email author
  1. 1.Harvard-MIT Division of Health Sciences and TechnologyHarvard Medical SchoolBostonUSA
  2. 2.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Dermatopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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