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Introduction to Precursor Neoplasms

  • Amrita Goyal
  • Joi B. Carter
  • Lyn McDivitt DuncanEmail author

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is the only “precursor neoplasm” and only myeloid malignancy included in the WHO-EORTC classification of cutaneous lymphomas. This exceptionally rare and very aggressive lymphoma is derived from blastic plasmacytoid dendritic cells, an uncommon subtype of dendritic cells. In contrast to our detailed knowledge of T-cell and B-cell biology, very little is known about the biology and function of normal blastic plasmacytoid dendritic cells.

Keywords

Blastic plasmacytoid dendritic cell neoplasm BPDCN Plasmacytoid monocytes Professional type-1 interferon producing cells 

References

  1. 1.
    Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research on Cancer; 2008.Google Scholar
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    Facchetti F, Jones D, Petrella T. Blastic plasmacytoid dendritic cell neoplasm. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid neoplasms 2. 4th ed. Lyon: International Agency for Research on Cancer; 2008. p. 145–7.Google Scholar
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    Jegalian AG, Facchetti F, Jaffe ES. Plasmacytoid dendritic cells: physiologic roles and pathologic states. Adv Anat Pathol. 2009;16:392–404.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amrita Goyal
    • 1
  • Joi B. Carter
    • 2
  • Lyn McDivitt Duncan
    • 3
    Email author
  1. 1.Harvard-MIT Division of Health Sciences and TechnologyHarvard Medical SchoolBostonUSA
  2. 2.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Dermatopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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