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Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

  • Amrita Goyal
  • Joi B. Carter
  • Jeffrey A. Barnes
  • Lyn McDivitt DuncanEmail author

Abstract

Primary cutaneous diffuse large B-cell lymphoma (pcDLBCL), leg type, is a rare B-cell lymphoma of post-germinal B cells. Although this lymphoma classically presents on the leg with erythematous or violaceous tumors or nodules, it can also present elsewhere on the body. Patients with pcDLBCL have a moderately poor prognosis and experience frequent systemic dissemination. Though small case series have reported dramatic improvements in survival with combination chemotherapy and rituximab, treatment is largely limited by patient age and functional status. This chapter discusses the clinical presentation, prognosis, treatment, histopathology, immunohistochemistry, molecular characteristics, and differential diagnosis of pcDLBCL. The chapter closes with two clinical cases: one case of pcDLBCL occurring on the leg and one occurring on the scalp.

Keywords

Primary cutaneous diffuse large B-cell lymphoma, leg type pcDLBCL CD20 Bcl2 Bcl6 FoxP1 Centroblast Immunoblast MALT lymphoma Pseudolymphoma 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amrita Goyal
    • 1
  • Joi B. Carter
    • 2
  • Jeffrey A. Barnes
    • 3
  • Lyn McDivitt Duncan
    • 4
    Email author
  1. 1.Harvard-MIT Division of Health Sciences and TechnologyHarvard Medical SchoolBostonUSA
  2. 2.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Comprehensive Cutaneous Lymphoma Program, Department of MedicineMassachusetts General Hospital Cancer CenterBostonUSA
  4. 4.Dermatopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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