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Primary Cutaneous Follicle Center Lymphoma

  • Amrita Goyal
  • Joi B. Carter
  • Jeffrey A. Barnes
  • Lyn McDivitt DuncanEmail author

Abstract

Primary cutaneous follicle center lymphoma (pcFCL) is an indolent B-cell lymphoma with a remarkably good prognosis. This neoplasm of mature germinal center B cells constitutes 60 % of all primary cutaneous B-cell lymphomas and 9–11 % of all cutaneous lymphomas [1, 2]. It also includes 5 % of all follicular lymphomas, nodal and extranodal [3]. It typically presents with firm, erythematous to violaceous papules, plaques, and tumors on the scalp, trunk, and upper extremities. When it occurs on the back, it has been referred to in the past as Crosti lymphoma or reticulohistiocytoma of the dorsum [1, 4]. Differentiation of pcFCL from systemic follicle center lymphomas is critical, given the substantially worse prognosis of systemic follicle center lymphomas. This chapter addresses the clinical presentation, prognosis, treatment, histopathology, immunophenotype, and differential diagnosis of pcFCL. It closes with two clinical cases, including clinical images and histopathology.

Keywords

Primary cutaneous follicle center lymphoma Follicular lymphoma Crosti’s CD20 Bcl2 Bcl6 Naked follicles Inside-out follicles MALT lymphoma Diffuse large B-cell lymphoma Cutaneous lymphoma hyperplasia Pseudolymphoma 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amrita Goyal
    • 1
  • Joi B. Carter
    • 2
  • Jeffrey A. Barnes
    • 3
  • Lyn McDivitt Duncan
    • 4
    Email author
  1. 1.Harvard-MIT Division of Health Sciences and TechnologyHarvard Medical SchoolBostonUSA
  2. 2.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Comprehensive Cutaneous Lymphoma Program, Department of MedicineMassachusetts General Hospital Cancer CenterBostonUSA
  4. 4.Dermatopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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