Introduction to the B-Cell Lymphomas

  • Amrita Goyal
  • Aliyah R. Sohani
  • Alexandra E. Kovach
  • Joi B. Carter
  • Jeffrey A. Barnes
  • Lyn McDivitt DuncanEmail author


The human body contains a vast array of B cells, with phenotypes ranging from the naïve B cell to the centrocyte, centroblast, immunoblast, plasmablast, and plasma cell. Each of these B-cell subsets has different functional, proliferative, and migratory capacities, and the diversity of cutaneous B-cell lymphoma (CBCL) reflects the variety of non-neoplastic B-cell counterparts. The WHO-EORTC classification [1] recognizes four cutaneous B-cell lymphomas: primary cutaneous marginal zone lymphoma (pcMZL or MALT lymphoma), primary cutaneous follicle-center lymphoma (pcFCL), primary cutaneous diffuse large B-cell lymphoma, leg-type (pcDLBCL), and intravascular large B-cell lymphoma (ivLBCL). Here we offer a schema for understanding and distinguishing these lymphomas. Each lymphoma is addressed individually in subsequent chapters.


B-cell Centrocyte Centroblast Immunoblast Plasmablast Plasma cell Primary cutaneous follicle center b-cell lymphoma Primary cutaneous marginal zone B-cell lymphoma Intravascular large B-cell lymphoma pcFCL pcMZL IVLBCL Diffuse large B-cell lymphoma pcDLBCL Follicle center cell Follicular dendritic cell Marginal zone cell BCL2 BCL6 CD10 MUM1] 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amrita Goyal
    • 1
  • Aliyah R. Sohani
    • 2
  • Alexandra E. Kovach
    • 3
  • Joi B. Carter
    • 4
  • Jeffrey A. Barnes
    • 5
  • Lyn McDivitt Duncan
    • 6
    Email author
  1. 1.Harvard-MIT Division of Health Sciences and TechnologyHarvard Medical SchoolBostonUSA
  2. 2.Hematopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Department of PathologyBoston Children’s HospitalBostonUSA
  4. 4.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  5. 5.Comprehensive Cutaneous Lymphoma Program, Department of MedicineMassachusetts General Hospital Cancer CenterBostonUSA
  6. 6.Dermatopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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