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Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma

  • Amrita Goyal
  • Joi B. Carter
  • Daniela Kroshinsky
  • Jeffrey A. Barnes
  • Aliyah R. Sohani
  • Lyn McDivitt DuncanEmail author

Abstract

Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (CD8+ AECTCL) is a rare, aggressive cutaneous T-cell lymphoma with a poor prognosis. Although CD8+ AECTCL typically initially presents on the skin, visceral dissemination is common. Given the rarity of this condition, it is considered a provisional entity in the fourth edition of the World Health Organization/European Organization for Research and Treatment of Cancer (WHO/EORTC) classification guidelines. In this chapter we discuss the clinical presentation, prognosis, treatment, histopathology, immunohistochemistry, molecular characteristics, and differential diagnosis of CD8+ AECTCL. The chapter closes with a clinical case.

Keywords

Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma Cytotoxic T cell Provisional entity Angiocentricity Angiodestruction Primary cutaneous gamma/delta T-cell lymphoma Extranodal NK/T cell lymphoma Lymphomatoid granulomatosis 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amrita Goyal
    • 1
  • Joi B. Carter
    • 2
  • Daniela Kroshinsky
    • 2
  • Jeffrey A. Barnes
    • 3
  • Aliyah R. Sohani
    • 4
  • Lyn McDivitt Duncan
    • 5
    Email author
  1. 1.Harvard-MIT Division of Health Sciences and TechnologyHarvard Medical SchoolBostonUSA
  2. 2.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Comprehensive Cutaneous Lymphoma ProgramDepartment of Medicine, Massachusetts General Hospital Cancer CenterBostonUSA
  4. 4.Hematopathology ServiceDepartment of Pathology Massachusetts General Hospital, Harvard Medical SchoolBostonUSA
  5. 5.Dermatopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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