Lymphomatoid Papulosis

  • Amrita Goyal
  • Joi B. Carter
  • Lyn McDivitt DuncanEmail author


Lymphomatoid papulosis (LyP) is a benign CD30+ lymphoproliferative disease that presents as recurrent, spontaneously healing crops of papules and nodules. There are four histologic variants of this lymphoma: types A, B, C, and D. Types B, C, and D resemble more aggressive lymphomas and can be difficult to differentiate from mycosis fungoides (MF), anaplastic large-cell lymphoma (ALCL), and CD8+ aggressive epidermotropic T-cell lymphoma (CD8+ AECTCL). Although LyP is benign and requires minimal treatment, it is occasionally associated with the development of malignant lymphomas, including MF, primary cutaneous ALCL, and Hodgkin lymphoma, thus mandating careful surveillance of patients with LyP. This chapter addresses the clinical presentation, prognosis, and treatment of LyP, followed by a discussion of the immunohistochemical, histopathologic, and molecular characteristics of the four subtypes. It closes with a clinical case.


Lymphomatoid papulosis CD30+ lymphoproliferative diseases Bexarotene Ultraviolet phototherapy Anaplastic large cell lymphoma Mycosis fungoides CD8+ aggressive epidermotropic T-cell lymphoma Pityriasis lichenoides et varioliformis acuta Type A Type B Type C Type D 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amrita Goyal
    • 1
  • Joi B. Carter
    • 2
  • Lyn McDivitt Duncan
    • 3
    Email author
  1. 1.Harvard-MIT Division of Health Sciences and TechnologyHarvard Medical SchoolBostonUSA
  2. 2.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Dermatopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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