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Heat Shock Proteins and Cancer: Plant Based Therapy

  • Chapter
Heat Shock Protein-Based Therapies

Part of the book series: Heat Shock Proteins ((HESP,volume 9))

Abstract

Cancer is one of the major causes of mortality in the world. Each year approximately 13 million people suffer from cancer disease, and approximately 60 % of them die because of cancer. Besides most of the patients response harmful side effects of chemo- and radiotherapies. Therefore the establishment of new therapeutic strategies for the treatment of cancers will be required. A number of studies have shown that some HSP are induced in specific tumor cells. For example, increased levels of HSP105, HSP90, HSP70, HSP60, HSP27 have been detected in colon cancer, lung cancer, hepatocellular carcinoma, colorectal cancer, and gliomas, respectively. Elevated HSP levels in tumor cells are suggested to be responsible for increased chemotherapy resistance and poor prognosis. Suppression of HSP expressions in cancer cells is a new strategy for the treatment. It is well known that some plant extracts and their flavonoids significantly decrease HSP expression, and induce apoptosis of cancer cells. In addition, using of the HSP inhibitors in association with classical chemotherapy increases the sensitivity of cancer cells to the cytotoxic drugs. Therefore, some plants and their biologically active natural compounds have been investigated for their possible contribution to cancer therapy. The current chapter reviews the role of HSP in different cancer types and suppressing HSP with some natural products.

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Abbreviations

17-AAG:

Tanespmycin

17-DMAG:

Retaspmycin

CDDP:

Cisplatin

CRC:

Colorectal carcinoma

Dox:

Doxorubicin

EGCG:

Epigallocatechin-3-gallate

ERK:

Extracellular signal-regulated kinase

GA:

Geldanamycin

Grp:

Glucose-regulated protein

HBV-related HCC:

Hepatit B virus-related hepatocellular carcinoma

HSE:

Heat shock element

HSF:

Heat shock factor

HSP:

Heat shock protein

JNK/SAPK:

Jun-amino-terminal kinase/stress-activated protein kinase

PA:

Peptide aptamer

PDTC:

Pyrrolidine dithiocarbamate

PEITC:

Phenethyl isothiocyanate

PES:

2-phenylethynesulfonamide

Phen:

1,10-phenanthroline

PTMs:

Posttranslational modifications

RCC:

Renal cell carcinoma

RP101:

Brivudine

siRNA:

Small interfering RNA

TF:

Theaflavins

TR:

Thearubigins

ZER:

Zerumbone

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Acknowledgements

The author thanks to Prof. Dr. Nazlı Arda (Istanbul University) for helpful advice, and Dr. Murat Pekmez (Istanbul University) and Dr. Farinaz Jafari Ghods (Istanbul University) for suggestions. This study was supported by the Research Fund of Istanbul University (Project no. T-746/13092005 and 4120).

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  1. Department of Molecular Biology & Genetics, Faculty of Science, Istanbul University, 34134, Vezneciler, Istanbul, Turkey

    Evren Önay-Uçar

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  1. Evren Önay-Uçar
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Correspondence to Evren Önay-Uçar .

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  1. Professor and VD for Research Innovations, Deanship for Scientific Research,, University of Dammam, Dammam, Saudi Arabia

    Alexzander A.A. Asea

  2. Deanship for Scientific Research and Preventive Dental Sciences Department, College of Dentistry, University of Dammam, Dammam, Saudi Arabia

    Naif N. Almasoud

  3. Gastrointestinal Translational Research, Center for Radiation Oncology Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Sunil Krishnan

  4. Department of Microbiology, Immunology & Biochemistry, Morehouse School of Medicine, Atlanta, Georgia, USA

    Punit Kaur

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Önay-Uçar, E. (2015). Heat Shock Proteins and Cancer: Plant Based Therapy. In: Asea, A., Almasoud, N., Krishnan, S., Kaur, P. (eds) Heat Shock Protein-Based Therapies. Heat Shock Proteins, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-17211-8_3

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