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Potential Applications of Nanoparticles for Hyperthermia

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Heat Shock Protein-Based Therapies

Part of the book series: Heat Shock Proteins ((HESP,volume 9))

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Abstract

There is converging evidence that clinical mild temperature hyperthermia sensitizes tumors to conventional therapies as chemotherapy and radiation therapy. Coupled with an increasing understanding of the biological basis of this synergy there has been a parallel increase in the ability to achieve, maintain, measure and monitor temperature and its physiological and physical consequences. A new entrant in the arena of hyperthermia generation is nanotechnology which capitalizes on locally injected or systemically administered nanoparticles that home to tumors and are activated by extrinsic energy sources to generate heat. This chapter highlights the unique opportunities and challenges with implementing hyperthermia mediated by a variety of engineered nanoparticles for cancer therapy.

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Abbreviations

AMF:

Alternating magnetic field

AuNRs:

Gold nanorods

AuNSs:

Gold-silica nanoshells

CTAB:

Cetylmethylamunium bromide

EGFR:

Epidermal growth factor receptor

EPR:

Enhanced permeability and retention

HAuNS:

Hollow gold nanoshells

MSH:

Melanocyte-stimulating hormone

MWCNTs:

Multi walled carbon nanotubes

NIR:

Near-infrared

PEG:

Polyethylene glycol

SAR:

Specific absorption rate

SPIONs:

Superparamagnetic iron oxide nanoparticles

SWCNTs:

Single walled carbon nanotubes

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Acknowledgements

This work was funded in part by grants from the National Institutes of Health (1R01CA155446, and U01CA151886), Department of Defense (PC111832), MD Anderson Institutional Research Grant, and the John E. and Dorothy J. Harris Endowed Professorship to SK.

Conflict of Interest The authors report no conflicts of interest.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA

    Caio César Quini

  2. Laboratory of Biomagnetism, Physics e Biophysics Department, Biosciences Institute, Univ Estadual Paulista, Botucatu, SP, Brazil

    Caio César Quini

  3. Gastrointestinal Translational Research, Center for Radiation Oncology Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Sunil Krishnan (Professor and Director)

Authors
  1. Caio César Quini
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  2. Sunil Krishnan
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Correspondence to Sunil Krishnan .

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Editors and Affiliations

  1. Professor and VD for Research Innovations, Deanship for Scientific Research,, University of Dammam, Dammam, Saudi Arabia

    Alexzander A.A. Asea

  2. Deanship for Scientific Research and Preventive Dental Sciences Department, College of Dentistry, University of Dammam, Dammam, Saudi Arabia

    Naif N. Almasoud

  3. Gastrointestinal Translational Research, Center for Radiation Oncology Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Sunil Krishnan

  4. Department of Microbiology, Immunology & Biochemistry, Morehouse School of Medicine, Atlanta, Georgia, USA

    Punit Kaur

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Quini, C.C., Krishnan, S. (2015). Potential Applications of Nanoparticles for Hyperthermia. In: Asea, A., Almasoud, N., Krishnan, S., Kaur, P. (eds) Heat Shock Protein-Based Therapies. Heat Shock Proteins, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-17211-8_11

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