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Combination Therapy (in the Treatment of Peyronie’s Disease)

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Peyronie’s Disease

Abstract

Multimodal therapy (MMT) is a term coined in the last century and derived from psychotherapy. MMT means that there are multiple modalities of each patient that should be addressed when both identifying and treating a psychological disorder.

In our different field of action, the concept may be applied in order to achieve a better therapeutic outcome. Similarly, we can devise a treatment plan that includes several therapeutic substances and/or treatment modalities in order to achieve greater results than each single drug or treatment modality. In this chapter are presented the most important studies where a combination therapy for Peyronie’s disease (PD) has been proposed and implemented. Various combinations of therapies were listed and presented as potential treatments for PD. The goal of combination therapy is to combine different mechanisms of action to enhance improvement in signs and symptoms of PD.

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References

  1. Lazarus AA (1989) The practice of multimodal therapy: systematic, comprehensive, and effective psychotherapy. Johns Hopkins University Press, Baltimore

    Google Scholar 

  2. Madsen HV (1948) Combination promin and streptomycin therapy for tuberculosis. Dis Chest 14(6):850–852

    Article  CAS  PubMed  Google Scholar 

  3. Kristenson A (1950) Treatment of cavernous pulmonary tuberculosis with a combination of chemotherapy and antibiotics. Acta Tuberc Scand Suppl 26:15–25

    CAS  PubMed  Google Scholar 

  4. Hetrick C, Ras R, Turri M (1970) Combined rifampicin-ethambutol therapy of resistant pulmonary tuberculosis. Effectiveness of various rifampicin doses in combination with ethambutol. Dtsch Med Wochenschr 95(36):1830–1833 [Article in German]

    Article  CAS  PubMed  Google Scholar 

  5. Gumbo T, Pasipanodya JG, Wash P et al (2014) Redefining multidrug-resistant tuberculosis based on clinical response to combination therapy. Antimicrob Agents Chemother 58(10):6111–6115

    Article  PubMed Central  PubMed  Google Scholar 

  6. Shapiro DM (1952) Combination chemotherapy with 8-azaguanine and sex hormones on a mouse mammary carcinoma. Cancer Res 12(10):713–715

    CAS  PubMed  Google Scholar 

  7. Shapiro DM, Gellhorn A (1941) Combination of chemical compounds in experimental cancer therapy. Cancer Res 11:35–41

    Google Scholar 

  8. Skipper HE (1949) Carbamates in the chemotherapy of leukemia. V. Observation of a possible antileukemic synergism between Orethan and Methylbis (3-chloroethyl)-amine. Cancer 2:475–479

    Article  CAS  PubMed  Google Scholar 

  9. Samadi N, Ghanbari P, Mohseni M et al (2014) Combination therapy increases the efficacy of docetaxel, vinblastine and tamoxifen in cancer cells. J Cancer Res Ther 10(3):715–721

    PubMed  Google Scholar 

  10. Ferulano O (1955) Effect of circular electrolysis combined with medical treatment (wydase and vitum E) in delayed plastic induration of penis; hypothesis on etiology and pathogenesis and clinical aspects. G Ital Chir 11(9):1049–1061 [Article in Italian]

    CAS  PubMed  Google Scholar 

  11. Burford EH, Burford CE (1957) Combined therapy for Peyronie’s disease. J Urol 78(3):265–268

    CAS  PubMed  Google Scholar 

  12. Kierkegaard E, Nielsen B (1979) Peyronie’s disease treated with K-para-aminobenzoate and vitamin E. Ugeskr Laeger 141(30):2052–2053 [Article in Danish]

    CAS  PubMed  Google Scholar 

  13. Novak GI (1984) Conservative treatment of Peyronie’s disease with vitamin E and hydrocortisone. Vestn Dermatol Venerol 8:63–68, Article in Russian

    PubMed  Google Scholar 

  14. Pastorini S, Marino G, Brigato R et al (1991) The therapy of plastic penile induration using superoxide dismutase per os and injection combined with vasoactive intracavernous pharmacotherapy. Minerva Urol Nefrol 43(2):75–78 [Article in Italian]

    CAS  PubMed  Google Scholar 

  15. Lamprakopoulos A, Zorzos I, Lykourinas M (2000) The use of betamethasone and Hyaluronidase injections in the treatment of Peyronie’s disease. Scand J Urol Nephrol 34(6):355–360

    Article  CAS  PubMed  Google Scholar 

  16. Cavallini G, Biagiotti G, Koverech A et al (2002) Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie’s disease. BJU Int 89(9):895–900

    Article  CAS  PubMed  Google Scholar 

  17. Prieto Castro RM, Leva Vallejo ME, Regueiro Lopez JC et al (2003) Combined treatment with vitamin E and colchicine in the early stages of Peyronie’s disease. BJU Int 91(6):522–524

    Article  CAS  PubMed  Google Scholar 

  18. Cakan M, Demirel F, Aldemir M et al (2006) Does smoking change the efficacy of combination therapy with vitamin E and colchicines in patients with early-stage Peyronie’s disease? Arch Androl 52(1):21–27

    Article  CAS  PubMed  Google Scholar 

  19. La Pera G, Pescatori ES, Calabrese M, SIMONA Study Group et al (2001) Peyronie’s disease: prevalence and association with cigarette smoking. A multicenter population-based study in men aged 50–69 years. Eur Urol 40(5):525–530

    Article  PubMed  Google Scholar 

  20. Candebat Montero LH, Miranda Reyes PL, Díaz García F et al (2008) Peyronie’s disease: treatment with interferon and laser. Arch Esp Urol 61(3):413–423 [Article in Spanish]

    Article  CAS  PubMed  Google Scholar 

  21. Taylor FL, Levine LA (2008) Non-surgical therapy of Peyronie’s disease. Asian J Androl 10(1):79–87

    Article  CAS  PubMed  Google Scholar 

  22. Cortés-González JR, Glina S (2010) Conservative treatment of Peyronie’s disease: colchicine vs. colchicine plus vitamin E. Actas Urol Esp 34(5):444–449 [Article in Spanish]

    Article  PubMed  Google Scholar 

  23. Kuehhas FE, Weibl P, Georgi T et al (2011) Peyronie’s disease: nonsurgical therapy options. Rev Urol 13(3):139–146

    PubMed Central  PubMed  Google Scholar 

  24. Larsen SM, Levine LA (2012) Review of non-surgical treatment options for Peyronie’s disease. Int J Impot Res 24(1):1–10

    Article  CAS  PubMed  Google Scholar 

  25. Abern MR, Larsen S, Levine LA (2012) Combination of penile traction, intralesional verapamil, and oral therapies for Peyronie’s disease. J Sex Med 9(1):288–295

    Article  CAS  PubMed  Google Scholar 

  26. Halal AA, Geavlete P, Ceban E (2012) Pharmacological therapy in patients diagnosed with Peyronie’s disease. J Med Life 5(2):192–195

    PubMed Central  CAS  PubMed  Google Scholar 

  27. Levine LA (2013) Peyronie’s disease: contemporary review of non-surgical treatment. Trans Androl Urol. 2(1). Available at: http://www.amepc.org/tau/article/view/1461

  28. Favilla V, Russo GI, Privitera S et al (2014) Combination of intralesional verapamil and oral antioxidants for Peyronie’s disease: a prospective, randomised controlled study. Andrologia 46(8):936–942

    Article  CAS  PubMed  Google Scholar 

  29. Paulis G, D’Ascenzo R, Nupieri P et al (2012) Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie’s disease: a study of 151 cases. Int J Androl 35(4):521–527

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  30. Paulis G, Cavallini G, Brancato T et al (2013) Peironimev-Plus® in the treatment of chronic inflammation of tunica albuginea (Peyronie’s disease). Results of a controlled study. Inflamm Allergy Drug Targets 12(1):61–67

    Article  CAS  PubMed  Google Scholar 

  31. Paulis G, Brancato T, D’Ascenzo R et al (2013) Efficacy of vitamin E in the conservative treatment of Peyronie's disease: legend or reality? A controlled study of 70 cases. Andrology 1(1):120–128

    Article  CAS  PubMed  Google Scholar 

  32. Paulis G, Cavallini G, De Giorgio G et al (2013) Long-term multimodal therapy (verapamil associated with propolis, blueberry, vitamin E and local diclofenac) on patients with Peyronie’s disease (chronic inflammation of the tunica albuginea). Results of a controlled study. Inflamm Allergy Drug Targets 12(6):403–409

    Article  CAS  PubMed  Google Scholar 

  33. Paulis G, Pirozzi Farina F et al (2014) Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Patients with Peyronie’s Disease. Results of a Controlled Study. Andrology Open Access 3:123

    Google Scholar 

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Correspondence to Gianni Paulis .

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Paulis, G. (2015). Combination Therapy (in the Treatment of Peyronie’s Disease). In: Cavallini, G., Paulis, G. (eds) Peyronie’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-17202-6_14

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  • DOI: https://doi.org/10.1007/978-3-319-17202-6_14

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17201-9

  • Online ISBN: 978-3-319-17202-6

  • eBook Packages: MedicineMedicine (R0)

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