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Eosinophilic Esophagitis

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Abstract

Eosinophilic esophagitis (EoE) is an allergen-mediated disorder characterized by symptoms of esophageal dysfunction and a marked eosinophilic infiltrate on esophageal biopsy. The intense intraepithelial eosinophil infiltration is accompanied by typical clinical, endoscopic, and histologic findings. Symptoms of esophageal dysfunction may mimic gastroesophageal reflux. EoE represents the first cause of food impaction in young males and the second most common cause of chronic esophagitis after gastroesophageal reflux disease (GERD). The gold standard for its diagnosis is the finding of more than 15 eosinophils in at least one microscopy high-power field on esophageal biopsy obtained by endoscopy. Clinical features and therapeutic approach in children are described.

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Author information

Authors and Affiliations

  1. Pediatric Liver, GI and Nutrition Centre, King’s College Hospital, SE5 9RS, Denmark Hill, London, UK

    Natalia Nedelkopoulou & Babu Vadamalayan

  2. Clinical Lead Liver Pathology, Institute of Liver Studies, King’s College Hospital, SE5 9RS, Denmark Hill, London, UK

    Alberto Quaglia

Authors
  1. Natalia Nedelkopoulou
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  2. Alberto Quaglia
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  3. Babu Vadamalayan
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Correspondence to Babu Vadamalayan .

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Editors and Affiliations

  1. Department of Pediatrics, University of Chicago, Chicago, Illinois, USA

    Stefano Guandalini

  2. Clinical Director Child Health King’s College Hospital, Professor and Director Pediatric Liver, GI and Nutrition Center, London, United Kingdom

    Anil Dhawan

  3. Department of Pediatrics, Hebrew University Hadassah Hospital, Jerusalem, Israel

    David Branski

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Nedelkopoulou, N., Quaglia, A., Vadamalayan, B. (2016). Eosinophilic Esophagitis. In: Guandalini, S., Dhawan, A., Branski, D. (eds) Textbook of Pediatric Gastroenterology, Hepatology and Nutrition. Springer, Cham. https://doi.org/10.1007/978-3-319-17169-2_9

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