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The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 854))

Abstract

Arf-like proteins (ARLs) are ubiquitously expressed small G proteins of the RAS superfamily. In photoreceptors, ARL2 and ARL3 participate in the trafficking of lipidated membrane-associated proteins and colocalize in the inner segment with UNC119A and PDEδ. UNC119A and PDEδ are acyl- and prenyl-binding proteins, respectively, involved in trafficking of acylated (transducin-α subunit, nephrocystin NPHP3) and prenylated proteins (GRK1, PDE6). Germline Arl3 knockout mice do not survive beyond postnatal day 21 and display ciliary defects in multiple organs (kidney, liver and pancreas) as well as retinal degeneration. Conditional knockouts will be necessary to delineate mechanisms of protein transport in retina disease.

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Authors and Affiliations

  1. Department of Physical Biochemistry, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476, Potsdam, Germany

    Christin Hanke-Gogokhia

  2. Department of Ophthalmology, John A. Moran Eye Center, University of Utah Health Science Center, 65 Mario Capecchi Drive, 84132, Salt Lake City, UT, USA

    Christin Hanke-Gogokhia, Jeanne M. Frederick & Wolfgang Baehr

  3. Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China

    Houbin Zhang

  4. Department of Neurobiology and Anatomy, University of Utah Health Science Center, 20 North 1900 East, Room 401 MREB, 84132, Salt Lake City, UT, USA

    Wolfgang Baehr

  5. Department of Biology, University of Utah, 257 South 1400 East, 84112, Salt Lake City, UT, USA

    Wolfgang Baehr

Authors
  1. Christin Hanke-Gogokhia
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  2. Houbin Zhang
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  3. Jeanne M. Frederick
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  4. Wolfgang Baehr
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Corresponding author

Correspondence to Wolfgang Baehr .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

  2. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  3. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  4. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  5. Case Western Reserve University Cleveland Clinic Lerner College of Med, Cleveland, Ohio, USA

    Joe Hollyfield

  6. Univ of Florida Dept of Ophthalmology/Arb R112, Gainesville, Florida, USA

    John Ash

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© 2016 Springer International Publishing Switzerland

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Hanke-Gogokhia, C., Zhang, H., Frederick, J., Baehr, W. (2016). The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_87

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