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The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair

Conference paper
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 854)

Abstract

Damage to mitochondria is a common mechanism of cell death in inherited neurodegenerative disorders. Therefore, mitochondrial protection and mitochondrial repair are promising strategies to induce retinal neuroprotection. Peroxisome proliferator-activated receptor γ coactivator-α (PGC-1α) and β (PGC-1β) are transcriptional coactivators that are the main regulators of mitochondrial biogenesis. We propose that PGC-1α and PGC-1β could play a role in regulating retina cell survival, and may be important therapeutic targets to prevent retinal degeneration.

Keywords

Neuroprotection Retina PGC-1alpha PGC-1beta Mitochondrial biogenesis 

Abbreviations

PGC-1α

Peroxisome proliferator-activated receptor γ coactivator-α

PGC-1β

Peroxisome proliferator-activated receptor γ coactivator-β

ROS

Reactive oxygen species

mtDNA

Mitochondrial DNA

NRF-1 and NRF-2

Nuclear respiratory factors -1 and 2

PPAR

Peroxisome proliferator-activated receptor

AMPK

Adenosine mono-phoshpate-dependent Kinase

UCP

Uncoupling protein

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Environmental Horticulture ResearchUniversity of FloridaGainesvilleUSA
  2. 2.Department of OphthalmologyUniversity of FloridaGainesvilleUSA

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