Skip to main content

Orthotopic Liver Transplantation

  • Chapter
  • 1480 Accesses

Abstract

The original technique of orthotopic liver transplantation (LT) envisages the removal of the native liver together with the infrahepatic inferior vena cava (IVC), while a subsequent evolution of this procedure includes the preservation of the IVC. In this latter case, the outflow reconstruction is achieved with an anastomosis of the donor IVC to the stump of the three major hepatic veins or to the IVC of the recipient. The two techniques had undergone a few modifications since their initial proposal. Although it is generally recognized that the preservation of the IVC carries some advantages in terms of shorter operation time, avoidance of venovenous bypass, and better hemodynamic stability and renal function, at present there is no definite agreement on which technique actually leads to better results. The sequence of vascular anastomosis is the same with the two techniques, that is, caval, portal, and arterial anastomoses, in an end-to-end fashion and with the general concept of avoiding an excessive length. Biliary reconstruction is the last step of the operation, and it is performed between the donor and recipient bile ducts or with a bilioenteric anastomosis.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Starzl TE, Marchioro TL, von Kaulla KN, Hermann G, Brittain RS, Waddell WR. Homotransplantation of the liver in humans. Surg Gynecol Obstet. 1963;117:659–76.

    PubMed Central  CAS  PubMed  Google Scholar 

  2. Starzl TE, Kaupp HA, Brock DR, Lazarus RE, Johnson RV. Reconstructive problems in canine liver homotransplantation with special reference to the postoperative role of hepatic venous flow. Surg Gynecol Obstet. 1960;111:733.

    PubMed Central  Google Scholar 

  3. Heisterkamp J, Marsman HA, Eker H, Metselaar HJ, Tilanus HW, Kazemier G. A J-shaped subcostal incision reduces the incidence of abdominal wall complications in liver transplantation. Liver Transpl. 2008;14:1655–8.

    Article  PubMed  Google Scholar 

  4. Kluger MD, Memeo R, Laurent A, Tayar C, Cherqui D. Survey of adult liver transplantation techniques (SALT): an international study of current practices in deceased donor liver transplantation. HPB. 2011;13:692–8.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Shaw Jr BW, Martin DJ, Marquez JM, et al. Venous bypass in clinical liver transplantation. Ann Surg. 1984;200:524–34.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Starzl TE, Iwatsuki S. A growth factor in fine vascular anastomoses. Surg Gynecol Obstet. 1984;159:164–6.

    PubMed Central  CAS  PubMed  Google Scholar 

  7. Todo S, Makowka L, Tzakis AG, et al. Hepatic artery in liver transplantation. Transpl Proc. 1987;19:2406–11.

    CAS  Google Scholar 

  8. Shaked A, Takill H, Busuttil RW. The use of supraceliac aorta for hepatic arterial revascularization in transplantation of the liver. Surg Gynecol Obstet. 1991;173:198–202.

    CAS  PubMed  Google Scholar 

  9. Vivarelli M, La Barba G, Cucchetti A, Lauro A, Del Gaudio M, Ravaioli M, Grazi GL, Pinna AD. Can antiplatelet prophylaxis reduce the incidence of hepatic artery thrombosis after liver transplantation? Liver Transpl. 2007;13:651–4.

    Article  PubMed  Google Scholar 

  10. Cescon M, zanello M, Grazi GL, Cucchetti A, Ravaioli M, Ercolani G, Del Gaudio M, Lauro A, Morelli MC, Pinna AD. Impact of very advanced donor age on hepatic artery thrombosis after liver transplantation. Transplantation. 2011;92:439–45.

    Article  PubMed  Google Scholar 

  11. Millis JM, Melinek J, Csete M, Imagawa DK, Olthoff KM, Neelankata G, Braunfeld MY, Sopher MJ, Chan SM, Pregler JL, Yersiz H, Busuttil AA, Shackleton CR, Shaked A, Busuttil RW. Randomized controlled trial to evaluate flush and reperfusion techniques in liver transplantation. Transplantation. 1997;63:397–403.

    Article  CAS  PubMed  Google Scholar 

  12. Polak WG, Porte RJ. The sequence of revascularization in liver transplantation: it does make a difference. Liver Transpl. 2006;12:1566–70.

    Article  PubMed  Google Scholar 

  13. Riediger C, Müller MW, Michalski CW, Hüser N, Schuster T, Kleeff J, Friess H. T-tube or no T-tube in the reconstruction of the biliary tract during orthotopic liver transplantation: systematic review and meta-analysis. Liver Transpl. 2010;16:705–17.

    PubMed  Google Scholar 

  14. Tzakis A, Todo S, Starzl TE. Orthotopic liver transplantation with preservation of the inferior vena cava. Ann Surg. 1989;210:649–52.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Belghiti J, Noun R, Sauvanet A. Temporary portocaval anastomosis with preservation of caval flow during orthotopic liver transplantation. Am J Surg. 1995;169:277–9.

    Article  CAS  PubMed  Google Scholar 

  16. Belghiti J, Panis Y, Sauvanet A, Gayet B, Fékété F. A new technique of side to side caval anastomosis during orthotopic hepatic transplantation without inferior vena caval occlusion. Surg Gynecol Obstet. 1992;175(3):270–2.

    CAS  PubMed  Google Scholar 

  17. Lerut J, Gertsch P. Side-to-side cavo-cavostomy: a useful aid in “complicated” piggy-back liver transplantation. Transpl Int. 1993;6:299–301.

    CAS  PubMed  Google Scholar 

  18. Jovine E, Mazziotti A, Grazi GL, et al. Piggy-back versus conventional technique in liver transplantation: report of a randomized trial. Transpl Int. 1997;10:109–12.

    Article  CAS  PubMed  Google Scholar 

  19. Gurusamy KS, Pamecha V, Davidson BR. Piggy-back graft for liver transplantation. Cochrane Database Syst Rev. 2011;(81):CD008258.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Matteo Cescon MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Cescon, M., Ercolani, G., Pinna, A.D. (2015). Orthotopic Liver Transplantation. In: Pinna, A., Ercolani, G. (eds) Abdominal Solid Organ Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-16997-2_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-16997-2_8

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-16996-5

  • Online ISBN: 978-3-319-16997-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics