Skip to main content
SpringerLink
Log in

Odontogenic Tumors: Malignant

  • Chapter
Pathology of the Maxillofacial Bones

  • 1754 Accesses

Abstract

Both odontogenic epithelium as well as odontogenic mesenchyme may show malignant neoplastic degeneration, causing either odontogenic carcinomas or odontogenic sarcomas. These are rare lesions with a varying outcome, some of them being very aggressive, others less devastating. In this Chapter the following entities are discussed: malignant ameloblastoma, ameloblastic carcinoma, primary intraosseous carcinoma, clear cell odontogenic carcinoma, sclerosing odontogenic carcinoma and odontogenic sarcoma. When considering a diagnosis of malignancy within the jaw bone, metastatic disease should be ruled out at first.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Barnes L, Eveson JW, Reichart PA, Sidransky D, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press; 2005. Chapter 6, Odontogenic Tumours; p. 283–327.

    Google Scholar 

  2. Slootweg PJ. Malignant odontogenic tumors; an overview. Mund Kiefer Gesichtschir. 2002;6(5):295–302.

    Article  CAS  PubMed  Google Scholar 

  3. Richardson MS, Muller S. Malignant odontogenic tumors: an update on selected tumors. Head Neck Pathol. 2014;8(4):411–20.

    Article  PubMed  Google Scholar 

  4. Kunze E, Donath K, Luhr HG, Engelhardt W, De Vivie R. Biology of metastasizing ameloblastoma. Pathol Res Pract. 1985;180(5):526–35.

    Article  CAS  PubMed  Google Scholar 

  5. Laughlin EH. Metastazing ameloblastoma. Cancer. 1989;64(3):776–80.

    Article  CAS  PubMed  Google Scholar 

  6. Elzay RP. Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol. 1982;54(3):299–303.

    Article  CAS  PubMed  Google Scholar 

  7. Jayaraj G, Sherlin HJ, Ramani P, Premkumar P, Natesan A, Ramasubramanian A, et al. Metastasizing Ameloblastoma – A perennial pathological enigma? Report of a case and review of literature. J Craniomaxillofac Surg. 2014;42(6):772–9.

    Article  PubMed  Google Scholar 

  8. Eversole LR. Malignant epithelial odontogenic tumors. Semin Diagn Pathol. 1999;16(4):317–24.

    CAS  PubMed  Google Scholar 

  9. Dhir K, Sciubba J, Tufano RP. Case report. Ameloblastic carcinoma of the maxilla. Oral Oncol. 2003;39(7):736–41.

    Article  PubMed  Google Scholar 

  10. Simko EJ, Brannon RB, Eibling DE. Ameloblastic carcinoma of the mandible. Head Neck. 1998;20(7):654–9.

    Article  CAS  PubMed  Google Scholar 

  11. Woolgar JA, Triantafyllou A, Ferlito A, Devaney KO, Lewis Jr JS, Rinaldo A, Slootweg PJ, Barnes L. Intraosseous carcinoma of the jaws: a clinicopathologic review. Part III: primary intraosseous squamous cell carcinoma. Head Neck. 2013;35(6):906–9.

    Article  PubMed  Google Scholar 

  12. Makowski GJ, McGuff S, van Sickels JE. Squamous cell carcinoma in a maxillary odontogenic keratocyst. J Oral Maxillofac Surg. 2001;59(1):76–80.

    Article  CAS  PubMed  Google Scholar 

  13. Slootweg PJ. Carcinoma arising from reduced enamel epithelium. J Oral Pathol. 1987;16(10):479–82.

    Article  CAS  PubMed  Google Scholar 

  14. Zwetyenga N, Pinsolle J, Rivel J, Majoufre-Lefebvre C, Faucher A, Pinsolle V. Primary intraosseous carcinoma of the jaws. Arch Otolaryngol Head Neck Surg. 2001;127(7):794–7.

    CAS  PubMed  Google Scholar 

  15. Hansen LS, Eversole LR, Green TL, Powell NB. Clear cell odontogenic tumor – a new histologic variant with aggressive potential. Head Neck Surg. 1985;8(2):115–23.

    Article  CAS  PubMed  Google Scholar 

  16. Eversole LR, Duffey DC, Powell NB. Clear cell odontogenic carcinoma. A clinicopathologic analysis. Arch Otolaryngol Head Neck Surg. 1995;121(6):685–9.

    Article  CAS  PubMed  Google Scholar 

  17. Maiorano E, Altini M, Viale G, Piatelli A, Favia G. Clear cell odontogenic carcinoma. Report of two cases and review of the literature. Am J Clin Pathol. 2001;116(1):107–14.

    Article  CAS  PubMed  Google Scholar 

  18. Brinck U, Gunawan B, Schulten HJ, Pinzon W, Fischer U, Fuezesi L. Clear cell odontogenic carcinoma with pulmonary metastases resembling pulmonary meningothelial-like nodules. Virchows Arch. 2001;438(4):412–7.

    Article  CAS  PubMed  Google Scholar 

  19. August M, Faquin W, Troulis M, Kaban L. Clear cell odontogenic carcinoma. Evaluation of reported cases. J Oral Maxillofac Surg. 2003;61(5):580–6.

    Article  PubMed  Google Scholar 

  20. Braunshtein E, Vered M, Taicher S, Buchner A. Clear cell odontogenic carcinoma and clear cell ameloblastoma. A single clinicopathologic entity? A new case and comparative analysis of the literature. J Oral Maxillofac Surg. 2003;61(9):1004–10.

    Article  PubMed  Google Scholar 

  21. Mosqueda-Taylor A, Neville BW, Tatemoto Y, Ogawa I, Takata T. Odontogenic carcinoma with dentinoid: a new odontogenic carcinoma. Head Neck Pathol. 2014;8(4):421–31.

    Article  PubMed  Google Scholar 

  22. Bilodeau EA, Weinreb I, Antonescu CR, Zhang L, Dacic S, Muller S, Barker B, Seethala RR. Clear cell odontogenic carcinomas show EWSR1 rearrangements: a novel finding and a biological link to salivary clear cell carcinomas. Am J Surg Pathol. 2013;37(7):1001–5.

    Article  PubMed  Google Scholar 

  23. Hirshberg A, Dayan D, Horowitz I. Dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg. 1987;16(5):620–5.

    Article  CAS  PubMed  Google Scholar 

  24. Lu Y, Mock D, Takata T, Jordan RC. Odontogenic ghost cell carcinoma: report of four new cases and review of the literature. J Oral Pathol Med. 1999;28(7):323–9.

    Article  CAS  PubMed  Google Scholar 

  25. Koutlas IG, Allen CM, Warnock GR, Manivel JC. Sclerosing odontogenic carcinoma: a previously unreported variant of a locally aggressive odontogenic neoplasm without apparent metastatic potential. Am J Surg Pathol. 2008;32(11):1613–9.

    Article  PubMed  Google Scholar 

  26. Woolgar JA, Triantafyllou A, Ferlito A, Devaney KO, Lewis Jr JS, Rinaldo A, Slootweg PJ, Barnes L. Intraosseous carcinoma of the jaws: a clinicopathologic review. Part II: odontogenic carcinomas. Head Neck. 2013;35(6):902–5.

    Article  PubMed  Google Scholar 

  27. Ide F, Ito Y, Muramatsu T, Saito I. Sclerosing odontogenic carcinoma: a morphologic pattern or pathologic entity? Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(6):839.

    Article  PubMed  Google Scholar 

  28. Iriè T, Ogawa I, Takata T, Toyosawa S, Saito N, Akiba M, et al. Sclerosing odontogenic carcinoma with benign fibro-osseous lesion of the mandible: an extremely rare case report. Pathol Int. 2010;60(10):694–700.

    Article  PubMed  Google Scholar 

  29. Slater LJ. Odontogenic sarcoma and carcinosarcoma. Semin Diagn Pathol. 1999;16(4):325–32.

    CAS  PubMed  Google Scholar 

  30. Altini M, Thompson SH, Lownie JF, Berezowski BB. Ameloblastic sarcoma of the mandible. J Oral Maxillofac Surg. 1985;43(10):789–94.

    Article  CAS  PubMed  Google Scholar 

  31. Muller S, Parker DC, Kapadia SB, Budnick SD, Barnes L. Ameloblastic fibrosarcoma of the jaws. A clinicopathologic and DNA analysis of five cases and review of the literature with discussion of its relationship to ameloblastic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(4):469–77.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    Pieter Slootweg

Authors
  1. Pieter Slootweg
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Slootweg, P. (2015). Odontogenic Tumors: Malignant. In: Pathology of the Maxillofacial Bones. Springer, Cham. https://doi.org/10.1007/978-3-319-16961-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-16961-3_6

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-16960-6

  • Online ISBN: 978-3-319-16961-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation