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Engineering Therapeutic Alignments Between Immune Response and Molecularly Targeted Cancer Treatment

  • Ariel Fernández Stigliano
Chapter

Abstract

In this chapter we develop molecular design strategies to empower drug-based anticancer therapy by restoring the immune response to drug-induced antigenic activity. We focus on reengineering immunosuppressive anticancer drugs where the impact on the immune system is an undesirable outcome, betraying their own raison d’être. The goal is to remove the immunosuppressive effects through molecular redesign, more specifically, to restore the adaptive immune response and natural killer cell cytotoxicity compromised by the original drug treatment. The redesign strategy enables us to create synergies that may empower drug-based anticancer therapy, aligning the immune response with the molecularly targeted treatment while retaining the anticancer efficacy of the parental compound.

Keywords

Anticancer Drug Adaptive Immune Response Stem Cell Factor Selectivity Filter Antigenic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.National Research Council–CONICETBuenos AiresArgentina
  2. 2.Former Karl F. Hasselmann Endowed Chair Professor of BioengineeringRice UniversityHoustonUSA

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