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Maternal Energetics and the Developmental Origins of Prostate Cancer in Offspring

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Murine Models, Energy Balance, and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 10))

Abstract

In 2014, Prostate cancer was the most commonly diagnosed cancer in men in the Western world, but few modifiable risk factors exist for this disease. Many studies have examined the association between obesity and prostate cancer incidence, producing conflicting results. However, maternal energetics during periconception and gestation has barely been considered as a potential risk factor, despite the fact that prostate tissue patterning and early development occur in utero. Maternal diabetes and obesity dramatically affect health at the time of pregnancy, and rodent and human studies demonstrate that the effects manifest in a variety of noncommunicable conditions in offspring, including early initiation of mammary tumors. Importantly, maternal diabetes and obesity directly alter the health of the early embryo and the maternal germ cell, or oocyte. Obesity-exposed oocytes exhibit alterations in size, gene expression, chromosome structure, and metabolism, and adult offspring present with defects including hyperplastic prostate tissues. We propose here that maternal obesity alters epigenetic and metabolic functions in the oocyte, which are passed to offspring, sensitizing them to precancerous conditions. Such an in utero environment could provide a “first hit” for prostate cancer development and should be considered when making dietary recommendations for expectant mothers.

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Acknowledgements

K.H.M. and E.C.B. were supported by the Washington University Transdisciplinary Research in Energetics and Cancer Program Grant (NCI; U54 CA 155496). E.C.B. was funded by the Washington University Department of Pathology Training Grant (5T32 DK 7296-33) and the Washington University Institute of Clinical and Translational Sciences grant UL1 TR000448 from the National Center for Advancing Translational Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Health (NIH). We thank Dr. Deborah Frank for suggestions on the manuscript and Michaela Reid for assistance with bibliography generation.

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  1. Department of Obstetrics and Gynecology, Washington University School of Medicine, 63110, St. Louis, MO, USA

    Emily C. Benesh PhD

  2. James P. Crane Professor, Department of Obstetrics and Gynecology, Washington University in Saint Louis, School of Medicine, 425 South Euclid Ave., BJC-IH 10th Floor, Campus Box 8064, 63110, Saint Louis, MO, USA

    Kelle H. Moley MD

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Correspondence to Kelle H. Moley MD .

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  1. Center for Science, Health & Society, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Nathan A. Berger

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Benesh, E., Moley, K. (2015). Maternal Energetics and the Developmental Origins of Prostate Cancer in Offspring. In: Berger, N. (eds) Murine Models, Energy Balance, and Cancer. Energy Balance and Cancer, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-319-16733-6_11

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