Protein Contact Prediction by Integrating Joint Evolutionary Coupling Analysis and Supervised Learning
Residue-residue contacts play an important role in maintaining the native fold of a protein and guiding protein folding. However, contact prediction from sequence is very challenging, as indicated by CASP10 , which shows that long-range contact prediction accuracy on hard targets is only ~20%.
KeywordsRandom Forest Supervise Learning Method Pfam Family Gaussian Graphical Model Contact Prediction
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