Abstract
Cells of lung epithelium are under a slow constant turn over in steady state and subject to rapid regeneration upon injury by inhaled or systemic pneumotoxicants. Multiple pools of adult stem cells have been shown to be involved in steady state airway maintenance and regeneration following injury. In this chapter, we summarize cellular diversity within adult mammalian airway epithelium that underscores challenges in maintenance and repair of the airway. We then briefly discuss distribution, mechanisms of identification and regulation of resident stem, and progenitor cell pools under steady state and in context of different injury models in mice. The ensuing chapters discuss some of these concepts at greater length and detail.
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We thank members of our lab for useful comments and discussion on the chapter.
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Ray, S., Stripp, B.R. (2015). Does a Lung Stem Cell Exist?. In: Firth, A., Yuan, JJ. (eds) Lung Stem Cells in the Epithelium and Vasculature. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-16232-4_1
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DOI: https://doi.org/10.1007/978-3-319-16232-4_1
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