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The Role of Steroid Hormone Receptors in the Establishment of Pregnancy in Rodents

Chapter
Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 216)

Abstract

The ovarian hormones, estrogen and progesterone, and their receptors, the estrogen receptor (ER) and progesterone receptor (PR), orchestrate the complex sequence of events required for uterine receptivity and the establishment of pregnancy. The actions of ER, PR, and other steroid hormone receptors (SHRs) direct the uterus through the processes of implantation and decidualization. Due to the ethical concerns of studying pregnancy in humans, genetically engineered rodent models have facilitated many of the discoveries that have elucidated the molecular events directing early pregnancy. This chapter will cover the conserved structure and function of the SHRs. ER and PR will be highlighted for their pivotal roles in uterine receptivity, implantation, and decidualization. The dynamic regulation of ER and PR expression and activity throughout the estrous cycle and early pregnancy, and the importance of SHRs in coordinating paracrine signaling between the endometrial compartments will also be explored. Finally, the roles of androgen receptor (AR) and glucocorticoid receptor (GR) in the establishment of pregnancy will be discussed.

Keywords

Androgen Receptor Progesterone Receptor Glucocorticoid Receptor Leukemia Inhibitory Factor Progesterone Receptor Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgments

This work was supported by NIH grants: R01HD042311, 5U54HD007495 (to FJD).

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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Translational Biology and Molecular Medicine Graduate ProgramBaylor College of MedicineHoustonUSA
  2. 2.Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonUSA

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