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Oxidative Stress and Hepatocellular Injury

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Studies on Hepatic Disorders

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Abstract

Oxidative stress and inflammation are hallmarks of virtually all (chronic) liver diseases. Not surprisingly, understanding the role of oxidative stress and its deleterious consequences has been and still is an important research topic in hepatology. A thorough understanding of oxidative stress and its impact on liver homeostasis is essential to identify novel targets for the treatment of liver diseases. In this chapter, we will review the current knowledge on the role of oxidative stress in hepatocellular injury. Hepatocytes have received a large share of the attention in research on oxidative stress. That will also be the case in this chapter. Nevertheless, we will also address the role of other liver cell types, such as endothelial cells, hepatic stellate cells, and Kupffer cells in oxidative stress-mediated liver injury.

*Author contributed equally with all other contributors.

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    Authors and Affiliations

    1. Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

      Marjolein H. Tiebosch, Golnar Karimian & Han Moshage

    2. Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

      Marjolein H. Tiebosch, Golnar Karimian & Han Moshage

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    1. Marjolein H. Tiebosch
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    2. Golnar Karimian
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    3. Han Moshage
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    Correspondence to Han Moshage .

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    Editors and Affiliations

    1. Department of Health Sciences, University of Eastern Piedmont Amedeo Avogadro, Novara, Italy

      Emanuele Albano

    2. Department of Clinical and Biological Sciences, Unit of Experimental Medicine and Clinical Pathology, School of Medicine, University of Torino, Torino, Italy

      Maurizio Parola

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    Tiebosch, M.H., Karimian, G., Moshage, H. (2015). Oxidative Stress and Hepatocellular Injury. In: Albano, E., Parola, M. (eds) Studies on Hepatic Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Cham. https://doi.org/10.1007/978-3-319-15539-5_4

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