Abstract
Among the various biological effects PFAS perfluoroalkyl and polyfluoroalkyl substances (PFAS) exert on living organisms, metabolic effects are important and have attracted considerable attention in PFAS studies in vitro and in vivo. Although PFAS are metabolically inert themselves, they can interfere with endogenous metabolic processes and thus do have the ability to exert effects on metabolism. The alteration on metabolism could induce a wide range of biochemical and physiological changes. Metabolic effects have various connections with other systemic toxicities induced by PFAS and potentially serve as the fundamental basis for other observed toxicities. Conversely, other systemic toxicities could potentially affect the metabolic balance of an organism, and thus induce secondary metabolic effects as well. This chapter discusses the molecular basis of PFAS-induced metabolic effects including experimental animal and human data regarding metabolic effects. While the major focus of this chapter is on metabolic effects, some systemic and organ-specific toxicities are also discussed, as it is necessary for a comprehensive discussion. A good understanding of PFAS-induced metabolic effects could help us to better handle the potential health risks associated with PFAS exposure.
Keywords
- Metabolic effects
- Structure-activity relationship
- Peroxisome proliferator-activated receptors
- Estrogen receptor
- Thyroid hormone receptor
- Leptin receptor
- Carbohydrates
- Fatty acids
- Uric acid
- Thyroid function
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Jiang, Q., Gao, H., Zhang, L. (2015). Metabolic Effects PFAS. In: DeWitt, J. (eds) Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-15518-0_7
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