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Metabolic Effects PFAS

  • Chapter
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

Among the various biological effects PFAS perfluoroalkyl and polyfluoroalkyl substances (PFAS) exert on living organisms, metabolic effects are important and have attracted considerable attention in PFAS studies in vitro and in vivo. Although PFAS are metabolically inert themselves, they can interfere with endogenous metabolic processes and thus do have the ability to exert effects on metabolism. The alteration on metabolism could induce a wide range of biochemical and physiological changes. Metabolic effects have various connections with other systemic toxicities induced by PFAS and potentially serve as the fundamental basis for other observed toxicities. Conversely, other systemic toxicities could potentially affect the metabolic balance of an organism, and thus induce secondary metabolic effects as well. This chapter discusses the molecular basis of PFAS-induced metabolic effects including experimental animal and human data regarding metabolic effects. While the major focus of this chapter is on metabolic effects, some systemic and organ-specific toxicities are also discussed, as it is necessary for a comprehensive discussion. A good understanding of PFAS-induced metabolic effects could help us to better handle the potential health risks associated with PFAS exposure.

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Authors and Affiliations

  1. Department of Pharmacology, Qingdao University Medical College, 422 Boya building, 308 Ningxia Road, Qingdao, 266071, Shandong, China

    Qixiao Jiang, Hui Gao & Lei Zhang

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  1. Qixiao Jiang
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  2. Hui Gao
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  3. Lei Zhang
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Correspondence to Qixiao Jiang .

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  1. Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA

    Jamie C. DeWitt

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Jiang, Q., Gao, H., Zhang, L. (2015). Metabolic Effects PFAS. In: DeWitt, J. (eds) Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-15518-0_7

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