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Mechanisms of Disease and Natural History

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Endovascular Aortic Repair

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Abstract

Timely prophylactic treatment of patients with aortic disease is critical for prevention of lethal complications such as aortic rupture or dissection. However, the timeliness of such treatment heavily relies on knowledge of the pathophysiology and natural history of aortic disease. In the era of rapidly emerging endovascular treatment options for patients with aortic disease as an alternative to classic open surgery, accurate prediction of the natural history is becoming increasingly important. Advances in understanding the genetics that underlie aortic pathology as well as the biomechanical processes that proceed within the diseased aortic wall will enable physicians to better predict the natural history of aortic disease in individual patients and thereby offer a more personalized management. In this chapter we review the current understanding of the mechanism of development and the natural history of thoracic aortic disease in the context of establishing evidence-based criteria for surgical/endovascular intervention.

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Authors and Affiliations

  1. Yale University School of Medicine, Aortic Institute at Yale-New Haven Hospital, 789 Howard Avenue, Clinic Building CB317, New Haven, CT, 06519, USA

    Bulat A. Ziganshin & John A. Elefteriades

  2. Department of Surgical Diseases 2, Kazan State Medical University, 49 Butlerov Street, Kazan, 420012, Russia

    Bulat A. Ziganshin

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  1. Bulat A. Ziganshin
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Correspondence to John A. Elefteriades .

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  1. Division of Vascular and Endovascular Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

    Gustavo S. Oderich

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Ziganshin, B.A., Elefteriades, J.A. (2017). Mechanisms of Disease and Natural History. In: Oderich, G. (eds) Endovascular Aortic Repair. Springer, Cham. https://doi.org/10.1007/978-3-319-15192-2_2

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  • DOI: https://doi.org/10.1007/978-3-319-15192-2_2

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