Abstract
The purpose of this study was to evaluate the anti-obesity and hypolipidemic effects of N-(β-d-Xylopyranosyl)taurine sodium salt (T-Xyl) supplementation in rats fed a high-fat diet and β-alanine. N-(β-d-Xylopyranosyl)taurine sodium salt is a newly synthesized compound with taurine and xylose. β-alanine was administered for induction of taurine depletion. Male Sprague-Dawley rats were randomly divided into seven groups with eight rats per group and fed for 6 weeks. Body weight gain and epididymal adipocyte size were significantly lower in HFTX2, 4, 6 (high-fat diet + 3 % β-alanine + T-Xyl 2, 4, 6 mmol/kg/day) groups compared to HF (high-fat diet) and HFA (high-fat diet + 3 % β-alanine) groups. Body weight (BW) and size of adipocytes in the HF and HFA groups increased significantly compared to the N (normal diet) group. The final BW, weight of relative epididymal fat (E-fat), and adipocyte size of the HF group were significantly higher, compared to that in the N group; however, administration of T-Xyl appeared to result in a decrease in those. The HA group showed a significant increase in serum total cholesterol (TC) level and calculated atherogenic index (AI) compared to the N group; however, administration of taurine and T-Xyl tended to result in a decrease in TC and AI. These results suggest that T-Xyl supplementation shows anti-obesity and hypolipidemic effects in rats fed a high-fat diet and β-alanine and may be absorbed through another transporter instead of a taurine transporter. Further study is needed in order to clarify the mechanism of T-Xyl action.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- T-Xyl:
-
N-(β-d-Xylopyranosyl)taurine sodium salt
- BW:
-
Body weight
- N:
-
Normal diet
- HF:
-
High-fat diet
- HFT:
-
High-fat diet + 4 mmol/kg/day taurine
- HFA:
-
High-fat diet + 3 % β-alanine
- HFTX2:
-
High-fat diet + 3 % β-alanine + 2 mmol/kg/day T-Xyl
- HFTX4:
-
High-fat diet + 3 % β-alanine + 4 mmol/kg/day T-Xyl
- HFTX6:
-
High-fat diet + 3 % β-alanine + 6 mmol/kg/day T-Xyl
- E-fat:
-
Epididymal fat
- R-fat:
-
Retroperitoneal fat
- TG:
-
Triglyceride
- TC:
-
Total cholesterol
- HDLC:
-
High density lipoprotein cholesterol
- LDLC:
-
Low density lipoprotein cholesterol
- AI:
-
Atherogenic index
- H&E:
-
Hematoxylin and eosin
- SEM:
-
Standard error of mean
References
Achike FI, To NHP, Wang H, Kwan CY (2011) Obesity, metabolic syndrome, adipocytes and vascular function: a holistic viewpoint. Clin Exp Pharmacol Physiol 38(1):1–10
Chang KJ (2002) Effect of taurine and β-alanine on blood glucose and blood lipid concentrations in streptozotocin-induced diabetic rats. Korean J Nutr 32(3):213–220
Cho HJ, You JS, Chang KJ, Kim KS, Kim SH (2014) Anti-adipogenic effect of taurine-carbohydrate derivatives. Bull Korean Chem Soc 35(6):1863
Chung EJ, Um YS, Nam HW, Park TS (2003) Changes in lipid peroxidation level and antioxidant enzyme activities of rats supplemented with dietary cholesterol and/or taurine. J Korean Soc Food Sci Nutr 32(8):1310–1317
Foos TM, Wu JY (2002) The role of taurine in the central nervous system and the modulation of intracellular calcium homeostasis. Neurochem Res 27(1–2):21–26
Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18(6):499–502
Haglund O, Luostarinen R, Wallin R, Wibell L, Saldenn T (1991) The effects of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin E. J Nutr 121:165–169
Hall JE (2003) The kidney, hypertension, and obesity. Hypertension 41(3):625–633
Kang KJ, Kim KJ, Choi SS, Han HK, Kwon SY (2004) Effects of instant coffee on weight, plasma lipids, leptin, and fat cell size in rats fed on a high fat diet. Korean J Food Sci Technol 36(3):478–483
Murakami S, Kondo-Ohta Y, Tomisawa K (1998) Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet. Life Sci 64(1):83–91
Rahmouni K, Correia ML, Haynes WG, Mark AL (2005) Obesity-associated hypertension new insights into mechanisms. Hypertension 45(1):9–14
Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123(11):1939–1951
Schurr A, Tseng MT, West CA, Rigor BM (1987) Taurine improves the recovery of neuronal function following cerebral hypoxia: an in vitro study. Life Sci 40(21):2059–2066
Sturman JA (1993) Taurine in development. Physiol Rev 73(1):119–147
Tsuboyama-Kasaoka N, Shozawa C, Sano K, Kamei Y, Kasaoka S, Hosokawa Y, Ezaki O (2006) Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Endocrinology 147(7):3276–3284
Zhang M, Bi L, Fang J, Su X, Da G, Kuwamori T, Kagamimori S (2004) Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids 26(3):267–271
Acknowledgements
This work was supported by grant from Inha University. We thank Dong-A Pharmaceutical Co. for the donation of taurine.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this paper
Cite this paper
You, J.S., Lee, Y.J., Kim, S.Y., Kim, S.H., Chang, K.J. (2015). Anti-obesity and Hypolipidemic Effects of N-(β-d-Xylopyranosyl) Taurine Sodium Salt Supplementation in Rats Fed a High-Fat Diet and β-Alanine. In: Marcinkiewicz, J., Schaffer, S. (eds) Taurine 9. Advances in Experimental Medicine and Biology, vol 803. Springer, Cham. https://doi.org/10.1007/978-3-319-15126-7_72
Download citation
DOI: https://doi.org/10.1007/978-3-319-15126-7_72
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-15125-0
Online ISBN: 978-3-319-15126-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)