Abstract
Taurine is one of the most abundant amino acids in the brain. It plays various important physiological functions as a neuromodulator and antioxidant. Taurine is suspected to be involved in depression as families that suffer from a hereditary taurine deficiency have a tendency to develop depression. However, knowledge regarding its function in relation to depression is limited. Previously, we reported that the chronic oral administration of taurine has an anti-depressant-like effect in rats and changes the phosphorylation levels of hippocampal signal transduction molecules including ERK and CaMKII. In this study, we studied the global changes of expression in hippocampal proteins and genes under chronic taurine supplementation. Wistar male rats were fed taurine-contained diet for 4 weeks. Hippocampal gene, protein expression and their phosphorylation levels were evaluated by the commercial microarrays. Some prominent changes of protein phosphorylation and expression levels in the taurine-fed rats were observed by the antibody microarray. Especially, hippocampal p53, Jun, PKCs and HDAC5 were overexpressed and/or phosphorylated in the taurine-fed rats compared to control. Also, DNA microarray showed some changes of hippocampal gene expression in the taurine-fed rats. In conclusion, our findings suggest that chronic taurine supplementation has an antidepressant-like effect via some changes of expression and phosphorylation of the hippocampal proteins.
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Abbreviations
- Akt:
-
Protein kinase B
- BDNF:
-
Brain-derived neurotrophic factor
- CaMKII:
-
Calcium/calmodulin-dependent protein kinase II
- CCL6:
-
Chemokine (C-C motif) ligand 6
- CD80:
-
Cluster of differentiation 80
- CMTM2a:
-
Chemokine-like factor-like MAL and related proteins for vesicle trafficking and membrane link domain transmembrane domain containing 2a
- CRABP1:
-
Cellular retinoic acid-binding protein 1
- CREB:
-
cAMP-response element-binding protein
- EAPP:
-
E2F-associated phosphoprotein
- ERK1/2:
-
Extracellular signal-regulated kinase1/2
- GSK3β:
-
Glycogen synthase kinase3-beta
- HDAC:
-
Histone deacetylase
- PKC:
-
Protein kinase C
- PLAC8:
-
Placentanspecific 8
- QOL:
-
Quality of life
- SPP1:
-
Secreted phosphoprotein 1
- SSRI:
-
Selective serotonin reuptake inhibitor
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Acknowledgements
We would like to thank Drs. Masaya Katsumata (Azabu University, Japan) and Teruo Miyazaki (Tokyo Medical University, Japan) for helpful comments regarding the manuscript. This research was supported in part by Ibaraki University Cooperation between Agriculture and Medicine (IUCAM) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and Morinaga Houshikai (Japan).
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Toyoda, A., Koike, H., Nishihata, K., Iio, W., Goto, T. (2015). Effects of Chronic Taurine Administration on Gene Expression, Protein Translation and Phosphorylation in the Rat Hippocampus. In: Marcinkiewicz, J., Schaffer, S. (eds) Taurine 9. Advances in Experimental Medicine and Biology, vol 803. Springer, Cham. https://doi.org/10.1007/978-3-319-15126-7_37
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DOI: https://doi.org/10.1007/978-3-319-15126-7_37
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