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Taurine Haloamines and Biofilm: II. Efficacy of Taurine Bromamine and Chlorhexidine Against Selected Microorganisms of Oral Biofilm

  • Conference paper
Taurine 9

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 803))

Abstract

Formation of bacterial biofilm on dental surfaces is characteristic for existence of oral microbiota. It was also proved that uncontrolled biofilms on dental surfaces, as well as on biomaterials used in dentistry, are the main cause of oral cavity diseases such as dental caries and periodontitis. For years chlorhexidine (CHX) has been known as an excellent antiseptic and anti-biofilm agent. However, due to some of its unwanted adverse effects novel antiseptics are currently being tested by many laboratories. Our preliminary data have suggested that taurine bromamine (TauBr), a strong antiseptic against planktonic form of various bacteria and an anti-inflammatory agent, may also be a good candidate for treatment of biofilm-associated infections. Nevertheless, beneficial therapeutic effect of TauBr in the treatment of inflammatory acne lesions was not fully supported in vitro in the experimental model of Pseudomonas aeruginosa biofilm. Such discrepancies may be explained by distinct antiseptic resistance of biofilms generated by different microbial species. In this study we have extended the investigations of anti-biofilm properties of TauBr using novel in vitro models of Streptoccocus mutans and Candida albicans biofilms formed on orthodontic appliances. The ability of TauBr to kill the experimental pathogens hidden in a mature biofilm was compared with that of CHX.

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Abbreviations

C. albicans :

Candida albicans

CFU:

Colony forming unit

CHX:

Chlorhexidine

HOCl:

Hypochlorous acid

MIC:

Minimal inhibitory concentration

NaOCl:

Sodium hypochlorite

P. gingivalis :

Porphyromonas gingivalis

S. mutans :

Streptococcus mutans

TauBr:

Taurine bromamine

TauCl:

Taurine chloramine

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Acknowledgments

 This paper was supported by Jagiellonian University Medical College grant no. K/ZDS/002964.

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Authors and Affiliations

  1. Department of Immunology, Jagiellonian University Medical College, 18 Czysta Street, Krakow, 31-121, Poland

    Ewa Pasich, Maria Walczewska, Angelika Peruń & Janusz Marcinkiewicz

  2. Center of Microbiological Research and Autovaccines Ltd, Krakow, Poland

    Anna Białecka & Andrzej Kasprowicz

Authors
  1. Ewa Pasich
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  2. Maria Walczewska
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  3. Anna Białecka
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  4. Angelika Peruń
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  5. Andrzej Kasprowicz
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  6. Janusz Marcinkiewicz
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Corresponding author

Correspondence to Janusz Marcinkiewicz .

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Editors and Affiliations

  1. Chair of Immunology, Medical College Jagiellonian University, Krakow, Poland

    Janusz Marcinkiewicz

  2. Department of Pharmacology, College of Medicine University of South Alabama, Mobile, Alabama, USA

    Stephen W. Schaffer

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Pasich, E., Walczewska, M., Białecka, A., Peruń, A., Kasprowicz, A., Marcinkiewicz, J. (2015). Taurine Haloamines and Biofilm: II. Efficacy of Taurine Bromamine and Chlorhexidine Against Selected Microorganisms of Oral Biofilm. In: Marcinkiewicz, J., Schaffer, S. (eds) Taurine 9. Advances in Experimental Medicine and Biology, vol 803. Springer, Cham. https://doi.org/10.1007/978-3-319-15126-7_12

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