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Autologous Mesenchymal Stem Cell Therapy in Patients with Stroke

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Cell Therapy for Brain Injury

Abstract

Cell therapy is an emerging paradigm in the stroke treatment field and is considered a potential regenerative strategy for patients with fixed neurologic deficits. Various cell types have been used to improve function and recovery after stroke, including embryonic stem cells, immortalized pluripotent stem cells, neural stem/progenitor cells, mononuclear cells, cell lines, and non-neuronal adult stem cells, such as mesenchymal stem cells (MSCs). This review will focus on the clinical applications of adult stem cell therapy, in particular, the use of autologous MSCs in stroke patients. The results of clinical trials, including the stem cell Application Research and Trials In NeuroloGy (STARTING) trial, are summarized together with the ongoing clinical trials of MSC therapy in adult stroke patients. In addition, the strategies to improve the therapeutic efficacy of MSCs that meet the FDA's regulations on stem cell use for clinical applications will be discussed, from bench (diverse cell sources and culture processes) to bedside (patient selection, blood-brain barrier manipulation, and outcome measures).

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Authors and Affiliations

  1. Department of Neurology, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, 135–710, Seoul, South Korea

    Oh Young Bang MD, PhD

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  1. Oh Young Bang MD, PhD
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Correspondence to Oh Young Bang MD, PhD .

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Editors and Affiliations

  1. Department of Neurology, Georgia Regents University, Augusta, Georgia, USA

    David C. Hess

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© 2015 Springer International Publishing Switzerland

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Bang, O. (2015). Autologous Mesenchymal Stem Cell Therapy in Patients with Stroke. In: Hess, D. (eds) Cell Therapy for Brain Injury. Springer, Cham. https://doi.org/10.1007/978-3-319-15063-5_3

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