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Inspired by the legend of Mithridates VI (born about 132 BC, died in 63 BC), the King of Pontus, mithridatism is the practice of protecting oneself against a poison by gradually self-administering various toxic products. This immunity is acquired via the repetitive and progressively increasing intake of these harmful substances. We could simply describe architecture and urbanism as two fields trying to become immune via some rather seriously dangerous phenomena, which I would like to describe here. The Hazard, the Image, the Seduction, the Fragmentation, the obligation to be Sophisticated, the Unknown, and the Overdose are some examples I will develop like a potential miscellanea of current architecture’s toxic substances. Some projects will try to address those issues.