Abstract
There has been tremendous interest in estimating the functional connectivity of neuronal activities across different brain regions using electromagnetic brain imaging.
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- 1.
Although the source has two components when the homogeneous spherical conductor model is used, for arguments in this chapter, we assume that the source vector has three \(x\), \(y\), and \(z\) components.
- 2.
If \( \varvec{ A }^T =- \varvec{ A } \) holds, matrix \( \varvec{ A } \) is skew-symmetric. Since \( \varvec{ \alpha }^T \varvec{ A } \varvec{ \alpha } \) is a scalar, if \( \varvec{ A } \) is skew-symmetric, \( \varvec{ \alpha }^T \varvec{ A } \varvec{ \alpha } =0\).
- 3.
The absolute value of the imaginary coherence is usually computed, because its sign has no meaning in expressing the connectivity.
- 4.
We can apply another method such as the false discovery rate to this multiple comparison problem.
References
J.-M. Schoffelen, J. Gross, Source connectivity analysis with MEG and EEG. Hum. Brain Mapp. 30, 1857–1865 (2009)
J. Gross, J. Kujara, M. Hämäläinen, L. Timmermann, A. Schnitzler, R. Salmelin, Dynamic imaging of coherent sources: studying neural interactions in the human brain. Proc. Natl. Acad. Sci. U.S.A. 98, 694–699 (2001)
A.G. Guggisberg, S.M. Honma, A.M. Findlay, S.S. Dalal, H.E. Kirsch, M.S. Berger, S.S. Nagarajan, Mapping functional connectivity in patients with brain lesions. Ann. Neurol. 63, 193–203 (2007)
P. Belardinelli, L. Ciancetta, M. Staudt, V. Pizzella, A. Londei, N.B.G.L. Romani, C. Braun, Cerebro-muscular and cerebro-cerebral coherence in patients with pre- and perinatally acquired unilateral brain lesions. NeuroImage 37, 1301–1314 (2007)
W.H.R. Miltner, C. Braun, M. Arnold, H. Witte, E. Taub, Coherence of gamma-band EEG activity as a basis for associative learning. Nature 397, 434–436 (1999)
K. Sekihara, S.S. Nagarajan, Adaptive Spatial Filters for Electromagnetic Brain Imaging (Springer, Berlin, 2008)
K. Sekihara, J.P. Owen, S. Trisno, S.S. Nagarajan, Removal of spurious coherence in MEG source-space coherence analysis. IEEE Trans. Biomed. Eng. 58, 3121–3129 (2011)
G. Nolte, O.B.L. Wheaton, Z. Mari, S. Vorbach, M. Hallett, Identifying true brain interaction from EEG data using the imaginary part of coherency. Clin. Neurophysiol. 115, 2292–2307 (2004)
R.D. Pascual-Marqui, Instantaneous and lagged measurements of linear and nonlinear dependence between groups of multivariate time series: frequency decomposition (2007). arXiv preprint arXiv:0711.1455
E.J. Hannan, Multiple Time Series, vol. 38 (Wiley, New York, 2009)
D.R. Brillinger, Time Series: Data Analysis and Theory, vol. 36 (Siam, Philadelphia, 2001)
A. Ewald, L. Marzetti, F. Zappasodi, F.C. Meinecke, G. Nolte, Estimating true brain connectivity from EEG/MEG data invariant to linear and static transformations in sensor space. NeuroImage 60(1), 476–488 (2012)
F. Shahbazi Avarvand, A. Ewald, G. Nolte, Localizing true brain interactions from EEG and MEG data with subspace methods and modified beamformers. Comput. Math. Methods Med. 2012, 402341 (2012)
A. Bruns, R. Eckhorn, Task-related coupling from high- to low-frequency signals among visual cortical areas in human subdural recordings. Int. J. Psychophysiol. 51, 97–116 (2004)
K. Sekihara, S.S. Nagarajan, Residual coherence and residual envelope correlation in MEG/EEG source-space connectivity analysis, in Conference of Proceedings of the IEEE Engineering in Medicine and Biology Society, pp. 4417–7 (2013)
J.F. Hipp, D.J. Hawellek, M. Corbetta, M. Siegel, A.K. Engel, Large-scale cortical correlation structure of spontaneous oscillatory activity. Nat. Neurosci. 15(6), 884–890 (2012)
J. Theiler, S. Eubank, A. Longtin, B. Galdrikian, J.D. Farmer, Testing for nonlinearity in time series: the method of surrogate data. Phys. D 58, 77–94 (1992)
L. Faes, G.D. Pinna, A. Porta, R. Maestri, G. Nollo, Surrogate data analysis for assessing the significance of the coherence function. IEEE Trans. Biomed. Eng. 51, 1156–1166 (2004)
Y. Benjamini, Y. Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289–300 (1995)
T.E. Nichols, S. Hayasaka, Controlling the familywise error rate in functional neuroimaging: Aj neural eng. comparative review. Stat. Methods Med. Res. 12, 419–446 (2003)
K.P. Westlake, L.B. Hinkley, M. Bucci, A.G. Guggisberg, A.M. Findlay, R.G. Henry, S.S. Nagarajan, N. Byl, Resting state alpha-band functional connectivity and recovery after stroke. Exp. Neurol. 237(1), 160–169 (2012)
P.E. Tarapore, A.M. Findlay, S.C. LaHue, H. Lee, S.M. Honma, D. Mizuiri, T.L. Luks, G.T. Manley, S.S. Nagarajan, P. Mukherjee, Resting state magnetoencephalography functional connectivity in traumatic brain injury: clinical article. J. Neurosurg. 118(6), 1306–1316 (2013)
L.B. Hinkley, J.P. Owen, M. Fisher, A.M. Findlay, S. Vinogradov, S.S. Nagarajan, Cognitive impairments in schizophrenia as assessed through activation and connectivity measures of magnetoencephalography (MEG) data. Front. Hum. Neurosci. 3, 73 (2009)
K.G. Ranasinghe, L.B. Hinkley, A.J. Beagle, D. Mizuiri, A.F. Dowling, S.M. Honma, M.M. Finucane, C. Scherling, B.L. Miller, S.S. Nagarajan et al., Regional functional connectivity predicts distinct cognitive impairments in Alzheimers disease spectrum. NeuroImage: Clin. 5, 385–395 (2014)
J. Sarvas, Basic mathematical and electromagnetic concepts of the biomagnetic inverse problem. Phys. Med. Biol. 32, 11–22 (1987)
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Sekihara, K., Nagarajan, S.S. (2015). Source-Space Connectivity Analysis Using Imaginary Coherence. In: Electromagnetic Brain Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-14947-9_7
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