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Embryological Basis for Vascular Anomalies

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Human Fetal Growth and Development

Abstract

Abnormal embryonic development of the vascular system causes a variety of vascular anomalies. Vasculogenesis is genetically determined with a specific sequence of formation, selective regression, and remodeling that must occur in the correct sequence to produce the typical mature vascular system. Investigation into the genes and signaling pathways that guide this complex process are crucial to understanding how vascular anomalies develop and may ultimately provide clues for therapeutic intervention or treatment of these conditions.

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References

  1. Patel-Hett S, D’Amore PA. Signal transduction in vasculogenesis and developmental angiogenesis. Int J Dev Biol. 2011;55(4–5):353–63. doi:10.1387/ijdb.103213sp.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Fancher TT, Muto A, Fitzgerald TN, Magri D, Gortler D, Nishibe T, Dardik A. Control of blood vessel identity: from embryo to adult. Ann Vasc Dis. 2008;1(1):28–34. doi:10.3400/avd.AVDrev07011. Epub 2008 Feb 15.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hong YK, Detmar M. Prox1, master regulator of the lymphatic vasculature phenotype. Cell Tissue Res. 2003;314(1):85–92. Oct. Epub 2003 Jul 22.

    Article  PubMed  Google Scholar 

  4. Schneider DJ, Moore JW. Patent ductus arteriosus. Circulation. 2006;114(17):1873–82.

    Article  PubMed  Google Scholar 

  5. Kenny D, Hijazi ZM. Coarctation of the aorta: from fetal life to adulthood. Cardiol J. 2011;18(5):487–95.

    Article  PubMed  Google Scholar 

  6. Cinà CS, Althani H, Pasenau J, Abouzahr L. Kommerell’s diverticulum and right-sided aortic arch: a cohort study and review of the literature. J Vasc Surg. 2004;39(1):131–9.

    Article  PubMed  Google Scholar 

  7. Ciervo A, Kahn M, Pangilinan AJ, Dardik H. Absence of the brachial artery: report of a rare human variation and review of upper extremity arterial anomalies. J Vasc Surg. 2001;33(1):191–4.

    Article  CAS  PubMed  Google Scholar 

  8. van Hooft IM, Zeebregts CJ, van Sterkenburg SM, de Vries WR, Reijnen MM. The persistent sciatic artery. Eur J Vasc Endovasc Surg. 2009;37(5):585–91.

    Article  PubMed  Google Scholar 

  9. Pillai J. A current interpretation of popliteal vascular entrapment. J Vasc Surg. 2008;48(6 Suppl):61S–5; discussion 65S.

    Article  PubMed  Google Scholar 

  10. Spentzouris G, Zandian A, Cesmebasi A, Kinsella CR, Muhleman M, Mirzayan N, Shirak M, Tubbs RS, Shaffer K, Loukas M. The clinical anatomy of the inferior vena cava: a review of common congenital anomalies and considerations for clinicians. Clin Anat. 2014;27(8):1234–43.

    Article  PubMed  Google Scholar 

  11. Natsis K, Tsitouridis I, Totlis T, Levva S, Tsikaras P, Skandalakis P. Proposal for classification of the circumaortic renal collar’s morphology. Am Surg. 2008;74(12):1190–4.

    PubMed  Google Scholar 

  12. Uhl JF, Gillot C, Chahim M. Anatomical variations of the femoral vein. J Vasc Surg. 2010;52(3):714–9.

    Article  PubMed  Google Scholar 

  13. Vural E, Ramakrishnan J, Cetin N, et al. The expression of vascular endothelial growth factor and its receptors in port-wine stains. Otolaryngol Head Neck Surg. 2008;139:560.

    Article  PubMed  Google Scholar 

  14. Shirley MD, Tang H, Gallione CJ, et al. Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med. 2013;368:1971.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gloviczki P, Driscoll DJ. Klippel-Trenaunay syndrome: current management. Phlebology. 2007;22(6):291–8.

    Article  CAS  PubMed  Google Scholar 

  16. Jacob AG, Driscoll DJ, Shaughnessy WJ, et al. Klippel-Trénaunay syndrome: spectrum and management. Mayo Clin Proc. 1998;73:28.

    Article  CAS  PubMed  Google Scholar 

  17. Koltowska K, Betterman KL, Harvey NL, Hogan BM. Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature. Development. 2013;140(9):1857–70.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Alan Dardik MD, PhD .

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Foster, T.R., Chin, J.A., Brownson, K.E., Bai, H., Dardik, A. (2016). Embryological Basis for Vascular Anomalies. In: Bhattacharya, N., Stubblefield, P. (eds) Human Fetal Growth and Development. Springer, Cham. https://doi.org/10.1007/978-3-319-14874-8_27

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  • DOI: https://doi.org/10.1007/978-3-319-14874-8_27

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-14873-1

  • Online ISBN: 978-3-319-14874-8

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