Skip to main content

Peripheral Nerve Diseases

  • Chapter
  • First Online:
Neuropathology Simplified
  • 2466 Accesses

Abstract

Peripheral nerve diseases are very uncommon, except in the elderly population, and in many cases the aetiology remains unknown despite investigations. In certain situations a nerve biopsy may be helpful in the investigation of patients, particularly where there is a reasonable likelihood of detecting a treatable disorder, and a skin biopsy may also help in confirming the presence of a small fibre neuropathy. The techniques for nerve biopsy and laboratory investigation are described, along with a detailed classification of peripheral neuropathies and their key pathological findings.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Donadio V, Incensi A, Leta V, Giannoccaro MP, Scaglione C, Martinelli P, et al. Skin nerve alpha-synuclein deposits: a biomarker for idiopathic Parkinson disease. Neurology. 2014;82(15):1362–9.

    Article  CAS  PubMed  Google Scholar 

  2. Doppler K, Werner C, Henneges C, Sommer C. Analysis of myelinated fibers in human skin biopsies of patients with neuropathies. J Neurol. 2012;259(9):1879–87.

    Article  PubMed  Google Scholar 

  3. Uceyler N, Devigili G, Toyka KV, Sommer C. Skin biopsy as an additional diagnostic tool in non-systemic vasculitic neuropathy. Acta Neuropathol. 2010;120(1):109–16.

    Article  PubMed  Google Scholar 

  4. Pollock M, Nukada H, Taylor P, Donaldson I, Carroll G. Comparison between fascicular and whole sural nerve biopsy. Ann Neurol. 1983;13(1):65–8.

    Article  CAS  PubMed  Google Scholar 

  5. French CSG. Recommendations on diagnostic strategies for chronic inflammatory demyelinating polyradiculoneuropathy. J Neurol Neurosurg Psychiatry. 2008;79(2):115–8.

    Google Scholar 

  6. Ormerod IE, Waddy HM, Kermode AG, Murray NM, Thomas PK. Involvement of the central nervous system in chronic inflammatory demyelinating polyneuropathy: a clinical, electrophysiological and magnetic resonance imaging study. J Neurol Neurosurg Psychiatry. 1990;53(9):789–93.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Vrancken AF, Gathier CS, Cats EA, Notermans NC, Collins MP. The additional yield of combined nerve/muscle biopsy in vasculitic neuropathy. Eur J Neurol. 2011;18(1):49–58.

    Article  CAS  PubMed  Google Scholar 

  8. Said G, Lacroix C. Primary and secondary vasculitic neuropathy. J Neurol. 2005;252(6):633–41.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Hilton, D.A., Shivane, A.G. (2015). Peripheral Nerve Diseases. In: Neuropathology Simplified. Springer, Cham. https://doi.org/10.1007/978-3-319-14605-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-14605-8_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-14604-1

  • Online ISBN: 978-3-319-14605-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics