Future Strategies for the Development of Desensitising Products
Dentine hypersensitivity (DH) is a clinical problem that may impact on the quality of life of individuals who experience discomfort when eating and drinking hot and cold food and drink during their day-to-day activities. Currently there is no ideal desensitising product (over the counter [toothpaste, gel or mouthwash] or dentist applied) that provides both fast-acting and long-lasting protection against the pain associated with DH. Currently toothpaste, gels and mouthwashe formulations are designed to reduce or relieve pain arising from DH based on either their (1) tubular-occluding components (e.g. silica, calcium carbonate, various apatites, oxalates or bioactive glass) or (2) nerve desensitisation properties (e.g. potassium ions) based on the hydrodynamic theory (see Chap. 2). A number of novel products have either been reformulated from existing products or developed as biomimetic materials as an alternative to the traditional desensitising products for treating DH, inhibiting caries and promoting remineralisation. The present chapter will focus attention on the physical and chemical properties of both traditional and novel products recommended for the treatment of DH as well as introducing more recent advances into the development of biomimetic products for the treatment of DH.
KeywordsBioactive Glass Calcium Phosphate Cement Dentine Tubule Dentine Surface Dentine Hypersensitivity
The authors would like to acknowledge the contribution of our colleagues in the preparation of the SEM images, namely, Dr. Delia Brauer, Dr. Natalia Karpukhina, Dr. Mohammed Mneimne, Dr. Xiaohui Chen, Dr. Saroash Shahid, Dr. Asad Mahmood, Dr. Allesia D’Onofrio and Tomas Duminis.
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