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Experimental Liver Transplantation and Surgery

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Rat Experimental Transplantation Surgery

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Abstract

Experimental microsurgical procedures in liver research conducted on rat models include liver transplantation, liver resection and portacaval shunt. Transplantation is technically challenging and the first successful rat liver transplant was performed ten years after the first human liver transplant. The rat liver transplantation model has been frequently used for testing organ preservation solutions and Ischemia-reperfusion injury. A subsequently developed partial liver graft transplantation model, used to investigate liver regeneration in combination with portal hypertension, has been used in research supporting the development of live donor liver transplantation. The other relevant interventions described here are portal vein (PV) and/or bile duct ligation.

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Author information

Authors and Affiliations

  1. Liver Unit, Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK

    Firas Zahr Eldeen & Hynek Mergental PhD

Authors
  1. Firas Zahr Eldeen
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  2. Hynek Mergental PhD
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Corresponding author

Correspondence to Hynek Mergental PhD .

Editor information

Editors and Affiliations

  1. Diabetes Center, Institute for Clinical Experimental Med. , Prague, Praha, Czech Republic

    Peter Girman

  2. Pancreatic Islet Lab. Diabetes Center, Institute for Clinical Experimental Med. , Prague, Praha, Czech Republic

    Jan Kriz

  3. Dept. of Transplantation Surgery, Institute for Clinical Experimental Med. , Prague, Praha, Czech Republic

    Peter Balaz

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© 2015 Springer International Publishing Switzerland

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Eldeen, F.Z., Mergental, H. (2015). Experimental Liver Transplantation and Surgery. In: Girman, P., Kriz, J., Balaz, P. (eds) Rat Experimental Transplantation Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-14559-4_11

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