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Biomarkers of Vascular Inflammation and Cardiovascular Disease

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Arterial Disorders

Abstract

Cardiovascular disease is the major cause of morbidity and mortality globally. As such better approaches for early detection and mechanism-targeted therapies are key priorities in cardiovascular research. Growing evidence indicates that vascular inflammation and oxidative stress may play an important role in the genesis and progression of cardiovascular disease. Accordingly identification of markers reflecting these processes may be useful early predictors of vascular damage and could provide insights into mechanisms, risk and targeted treatment. The present chapter provides a brief overview of vascular damage in cardiovascular disease and discusses recently identified novel biomarkers of vascular inflammation and oxidative stress. The potential clinical relevance is also highlighted.

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Acknowledgements

Work from the author’s laboratory was supported by grants 44018, from the Canadian Institutes of Health Research (CIHR), and grants from the British Heart Foundation (BHF). RMT is supported through a BHF Chair, PW through a BHF Fellowship, MD through a Marie Curie ITN (RADOX) and ACM through a Leadership Fellowship from the University of Glasgow.

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  1. Institute of Cardiovascular and Medical Sciences, British Heart Foundation (BHF) Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK

    Paul Welsh PhD, David Preiss MBBCh, PhD, Sofia Tsiropoulou PhD, Francisco J. Rios PhD, Adam Harvey PhD, Maria G. Dulak-Lis MSc, Augusto C. Montezano PhD & Rhian M. Touyz MBBCh, MD, PhD

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  1. Paul Welsh PhD
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  2. David Preiss MBBCh, PhD
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Correspondence to Rhian M. Touyz MBBCh, MD, PhD .

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  1. American University of Beirut Medical Center, Beirut, Lebanon

    Adel Berbari

  2. University of Milano Bicocca IRCCS Istituto Auxologico Italiano, Milan, Italy

    Giuseppe Mancia

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Welsh, P. et al. (2015). Biomarkers of Vascular Inflammation and Cardiovascular Disease. In: Berbari, A., Mancia, G. (eds) Arterial Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-14556-3_9

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