Tissue-Specific Functions and Regulation of Protein Kinase CK2

  • Sabrina Welker
  • Christina Servas
  • Meng Rui
  • Claudia Götz
  • Mathias MontenarhEmail author
Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 12)


CK2 is a ubiquitously expressed protein kinase which seems to be required for the viability of cells. An increasing number of CK2 substrates raise the questions how CK2 can phosphorylate so many different substrates and how these phosphorylation reactions are regulated. One key answer to these questions seems to be the subcellular localization of CK2 and its individual subunits. Here, we have addressed another strategy for the regulation of CK2, i.e. a tissue-specific expression, subcellular localization and tissue-specific substrates. In the case of pancreatic β-cells, we show that there is a hormonal impact by insulin which is similar to the hormonal regulation by androgens in prostate cancer cells. Furthermore, the subcellular localization of CK2 is specifically regulated by the metabolic status, i.e. glucose concentration in the pancreatic β-cells. Also the enzymatic activity as well as the binding to a pancreas-specific transcription factor Pdx-1 is modulated by the glucose concentration in pancreatic β-cells. Furthermore, the CK2 kinase activity seems to be an important survival factor for pancreatic β-cells. Thus, one key for the understanding of the pleiotropic effects of CK2 seems to be the determination of the regulation of CK2 in specific tissues.


Protein kinase CK2 Phosphorylation Pancreas Islet Beta cells Transcription factor 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Sabrina Welker
    • 1
  • Christina Servas
    • 1
  • Meng Rui
    • 1
  • Claudia Götz
    • 1
  • Mathias Montenarh
    • 1
    Email author
  1. 1.Medizinische Biochemie und MolekularbiologieUniversität des SaarlandesHomburgGermany

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