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History of the Discovery of Poly (ADP-ribose)

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PARP Inhibitors for Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D,volume 83))

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Abstract

This chapter describes the discovery of poly (ADP-ribose) and its associated enzymes, and the discovery of the function of poly (ADP-ribose) polymerase (PARP) in DNA repair and in the dynamic modification of chromatin. Poly (ADP-ribose) is a very unusual polymer in biology, it is ubiquitous in eukaryotes and functions crucially in the cellular response to DNA damage and probably also in chromatin conformation changes.

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Correspondence to Takashi Sugimura .

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Sugimura, T., Shall, S. (2015). History of the Discovery of Poly (ADP-ribose). In: Curtin, N., Sharma, R. (eds) PARP Inhibitors for Cancer Therapy. Cancer Drug Discovery and Development, vol 83. Humana Press, Cham. https://doi.org/10.1007/978-3-319-14151-0_1

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  • DOI: https://doi.org/10.1007/978-3-319-14151-0_1

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-14150-3

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