Abstract
Lower urinary tract (LUT) dysfunction is a leading cause of pediatric end-stage renal disease (ESRD). It is estimated that 15–25 % of children with ESRD have associated anatomic urological abnormalities that result in LUT dysfunction [1]. These problems may persist into adulthood and also comprise an important cause of ESRD in approximately 6 % of the older population [2]. It was previously thought that renal transplantation in the setting of an abnormal LUT was unfeasible and these patients were generally considered poor candidates for transplantation [1, 3–5].
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References
Koo HP, et al. Renal transplantation in children with severe lower urinary tract dysfunction. J Urol. 1999;161(1):240–5.
Sullivan ME, Reynard JM, Cranston DW. Renal transplantation into the abnormal lower urinary tract. BJU Int. 2003;92(5):510–5.
Cairns HS, et al. Renal transplantation into abnormal lower urinary tract. Lancet. 1991;338(8779):1376–9.
Nahas WC, et al. Kidney transplantation in patients with bladder augmentation: surgical outcome and urodynamic follow-up. Transplant Proc. 1997;29(1–2):157–8.
Crowe A, et al. Renal transplantation following renal failure due to urological disorders. Nephrol Dial Transplant. 1998;13(8):2065–9.
Kelly WD, Merkel FK, Markland C. Ileal urinary diversion in conjunction with renal homotransplantation. Lancet. 1966;1(7431):222–6.
Tunner WS, et al. Renal transplantation in children with corrected abnormalities of the lower urinary tract. J Urol. 1971;106(1):133–9.
Marshall FF, et al. The urological evaluation and management of patients with congenital lower urinary tract anomalies prior to renal transplantation. J Urol. 1982;127(6):1078–81.
Stephenson TP, et al. Urinary tract reconstruction before renal transplantation. Transplant Proc. 1984;16(5):1340–1.
Heritier P, et al. Renal transplantation and Kock pouch: a case report. J Urol. 1989;141(3):595–6.
Riley P, et al. Challenges facing renal transplantation in pediatric patients with lower urinary tract dysfunction. Transplantation. 2010;89(11):1299–307.
Al-Khudairi N, et al. Interventions for impaired bladders in paediatric renal transplant recipients with lower urinary tract dysfunction. Transpl Int. 2013;26(4):428–34.
Burns MW, et al. Treatment of bladder dysfunction in children with end-stage renal disease. J Pediatr Surg. 1992;27(2):170–4.
Zermann DH, et al. Diagnostic value of natural fill cystometry in neurogenic bladder in children. Eur Urol. 1997;32(2):223–8.
McGuire EJ, et al. Prognostic value of urodynamic testing in myelodysplastic patients. J Urol. 1981;126(2):205–9.
Lopez Pereira P, et al. Does treatment of bladder dysfunction prior to renal transplant improve outcome in patients with posterior urethral valves? Pediatr Transplant. 2000;4(2):118–22.
Peters C, Rushton HG. Vesicoureteral reflux associated renal damage: congenital reflux nephropathy and acquired renal scarring. J Urol. 2010;184(1):265–73.
Alfrey EJ, et al. Use of an augmented urinary bladder can be catastrophic in renal transplantation. Transplant Proc. 1997;29(1–2):154–5.
Basiri A, et al. Kidney transplantation in children with augmentation cystoplasty. J Urol. 2007;178(1):274–7; discussion 277.
Davis ID, et al. Pediatric renal transplantation: indications and special considerations. A position paper from the Pediatric Committee of the American Society of Transplant Physicians. Pediatr Transplant. 1998;2(2):117–29.
Dyer LL, Franco I. Botulinum toxin-A therapy in pediatric urology: indications for the neurogenic and non-neurogenic neurogenic bladder. ScientificWorldJournal. 2009;9:1300–5.
Kogan SJ, Levitt SB. Bladder evaluation in pediatric patients before undiversion in previously diverted urinary tracts. J Urol. 1977;118(3):443–6.
Cerilli J, et al. Renal transplantation in patients with urinary tract abnormalities. Surgery. 1976;79(3):248–52.
Errando C, et al. Urodynamic evaluation and management prior to renal transplantation. Eur Urol. 2000;38(4):415–8.
Alam S, Sheldon C. Urological issues in pediatric renal transplantation. Curr Opin Urol. 2008;18(4):413–8.
Serrano DP, et al. Transplantation into the long-term defunctionalized bladder. J Urol. 1996;156(3):885–8.
Neild GH, et al. Renal transplantation in adults with abnormal bladders. Transplantation. 2004;77(7):1123–7.
Nahas WC, et al. Comparison of renal transplantation outcomes in children with and without bladder dysfunction. A customized approach equals the difference. J Urol. 2008;179(2):712–6.
Basiri A, et al. Kidney transplantation before or after augmentation cystoplasty in children with high-pressure neurogenic bladder. BJU Int. 2009;103(1):86–8; discussion 88.
Garat JM, et al. Kidney transplants in patients with bladder augmentation: correlation and evolution. Int Urol Nephrol. 2009;41(1):1–5.
Hatch DA, et al. Kidney transplantation in children with urinary diversion or bladder augmentation. J Urol. 2001;165(6 Pt 2):2265–8.
Barry JM. Kidney transplantation into patients with abnormal bladders. Transplantation. 2004;77(7):1120–3.
Franc-Guimond J, Gonzalez R. Renal transplantation in children with reconstructed bladders. Transplantation. 2004;77(7):1116–20.
Nahas WC, et al. Clinical and urodynamic evaluation after ureterocystoplasty and kidney transplantation. J Urol. 2004;171(4):1428–31.
Sheldon CA, et al. Renal transplantation into the dysfunctional bladder: the role of adjunctive bladder reconstruction. J Urol. 1994;152(3):972–5.
Fontaine E, et al. Renal transplantation in children with augmentation cystoplasty: long-term results. J Urol. 1998;159(6):2110–3.
Tsai SY, et al. Terminal loop cutaneous ureterostomy in renal transplantation: an under utilized urinary diversion technique. J Urol. 2005;174(5):1906–9; discussion 1909.
Kim Jr CO, Gosalbez Jr R, Burke 3rd GW. Simultaneous ureterocystoplasty and living related renal transplantation. Clin Transplant. 1996;10(4):333–6.
Jones J, et al. Synchronous bladder augmentation and living related kidney transplantation. Urol Int. 2001;67(1):84–5.
Luke PP, et al. Long-term results of pediatric renal transplantation into a dysfunctional lower urinary tract. Transplantation. 2003;76(11):1578–82.
Taghizadeh A, et al. Ureterocystoplasty is safe and effective in patients awaiting renal transplantation. Urology. 2007;70(5):861–3.
Nguyen DH, et al. The syndrome of dysuria and hematuria in pediatric urinary reconstruction with stomach. J Urol. 1993;150(2 Pt 2):707–9.
Reinberg Y, et al. Perforation of the gastric segment of an augmented bladder secondary to peptic ulcer disease. J Urol. 1992;148(2 Pt 1):369–71.
Landau EH, et al. Renal transplantation in children following augmentation ureterocystoplasty. Urology. 1997;50(2):260–2.
Kurzrock EA, et al. Ureterocystoplasty (bladder augmentation) with a solitary kidney. Pediatr Transplant. 2002;6(3):240–3.
Kim MS, Primack W, Harmon WE. Congenital nephrotic syndrome: preemptive bilateral nephrectomy and dialysis before renal transplantation. J Am Soc Nephrol. 1992;3(2):260–3.
Mitrofanoff P. [Trans-appendicular continent cystostomy in the management of the neurogenic bladder]. Chir Pediatr. 1980;21(4):297–305.
Nie Z, et al. Comparison of urological complications with primary ureteroureterostomy versus conventional ureteroneocystostomy. Clin Transplant. 2010;24(5):615–9.
Campbell MF, Wein AJ, Kavoussi LR. Campbell-Walsh Urology. “Ch 136: urologic considerations in pediatric renal transplantation”, vol. 4. 10th ed. Philadelphia: Saunders; 2011.
Capizzi A, et al. Kidney transplantation in children with reconstructed bladder. Transplantation. 2004;77(7):1113–6.
Mathoera RB, Kok DJ, Nijman RJ. Bladder calculi in augmentation cystoplasty in children. Urology. 2000;56(3):482–7.
Palmer LS, et al. Urolithiasis in children following augmentation cystoplasty. J Urol. 1993;150(2 Pt 2):726–9.
Castellan M, et al. Complications after use of gastric segments for lower urinary tract reconstruction. J Urol. 2012;187(5):1823–7.
Higuchi TT, et al. Augmentation cystoplasty and risk of neoplasia: fact, fiction and controversy. J Urol. 2010;184(6):2492–6.
Warshaw BL, et al. Renal transplantation in children with obstructive uropathy. J Urol. 1980;123(5):737–41.
Reinberg Y, et al. The outcome of renal transplantation in children with posterior urethral valves. J Urol. 1988;140(6):1491–3.
Churchill BM, et al. Factors influencing patient and graft survival in 300 cadaveric pediatric renal transplants. J Urol. 1988;140(5 Pt 2):1129–33.
Mochon M, et al. Urinary tract infections in children with posterior urethral valves after kidney transplantation. J Urol. 1992;148(6):1874–6.
Salomon L, et al. Posterior urethral valves: long-term renal function consequences after transplantation. J Urol. 1997;157(3):992–5.
Broniszczak D, et al. Kidney transplantation in children with bladder augmentation or ileal conduit diversion. Eur J Pediatr Surg. 2010;20(1):5–10.
Djakovic N, et al. Intestinal reconstruction of the lower urinary tract as a prerequisite for renal transplantation. BJU Int. 2009;103(11):1555–60.
Taghizadeh AK, et al. Renal transplantation or bladder augmentation first? A comparison of complications and outcomes in children. BJU Int. 2007;100(6):1365–70.
Mendizabal S, et al. Renal transplantation in children with severe bladder dysfunction. J Urol. 2005;173(1):226–9.
Rigamonti W, et al. Kidney transplantation into bladder augmentation or urinary diversion: long-term results. Transplantation. 2005;80(10):1435–40.
Ali-El-Dein B, et al. Renal transplantation in children with abnormal lower urinary tract. Transplant Proc. 2004;36(10):2968–73.
DeFoor W, et al. Lower urinary tract reconstruction is safe and effective in children with end stage renal disease. J Urol. 2003;170(4 Pt 2):1497–500; discussion 1500.
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Tran, C., Rabets, J. (2015). Renal Transplantation in Patients with Lower Urinary Tract Dysfunction. In: Wood, H., Wood, D. (eds) Transition and Lifelong Care in Congenital Urology. Current Clinical Urology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-14042-1_14
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DOI: https://doi.org/10.1007/978-3-319-14042-1_14
Publisher Name: Humana Press, Cham
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