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Bone Morphogenetic Protein 7: An Emerging Therapeutic Target for Sepsis-associated Acute Kidney Injury

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Annual Update in Intensive Care and Emergency Medicine 2015

Part of the book series: Annual Update in Intensive Care and Emergency Medicine 2015 ((AUICEM,volume 2015))

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Abstract

Acute kidney injury (AKI) is a common organ dysfunction with poor prognosis. A recent study found that hospital mortality for adults with AKI was 23.9%, and 13.8% in children [1]. A prospective study of patients in the intensive care unit (ICU) with severe AKI (most receiving dialysis) reported a 60% hospital mortality rate, and 13.8% of survivors were dialysis-dependent at the time of hospital discharge [2]. Researchers have focused on preventing AKI and promoting its recovery; however, this has been difficult because the pathophysiological mechanisms responsible for AKI are still unclear.

Transforming growth factor-β (TGF-β)1 is believed to be an important molecule in AKI pathogenesis, especially for fibrosis, and its expression is decreased in chronic kidney disease (CKD) and late AKI [3]. It is generally believed that downregulation of TGF-β1 inhibits the process of fibrosis, but may promote inflammation [4]. Although Hiraki et al. reported that TGF-β1 neutralizing antibody improved survival rates of septic mice [5], modulation of the immune response can be difficult in sepsis especially since one cannot easily pinpoint the immune status at the bedside. Therefore, at the present time, the application of immune modulating therapy, including TGF-β1, is limited.

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Authors and Affiliations

  1. The Center of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA

    X. Chen, X. Wen & J. A. Kellum

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  1. X. Chen
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  2. X. Wen
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  3. J. A. Kellum
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Correspondence to J. A. Kellum .

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Editors and Affiliations

  1. Université libre de Bruxelles, Dept. of Intensive Care, Erasme Hospital, Brussels, Belgium

    Jean-Louis Vincent Prof.

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Chen, X., Wen, X., Kellum, J.A. (2015). Bone Morphogenetic Protein 7: An Emerging Therapeutic Target for Sepsis-associated Acute Kidney Injury. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2015. Annual Update in Intensive Care and Emergency Medicine 2015, vol 2015. Springer, Cham. https://doi.org/10.1007/978-3-319-13761-2_27

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  • DOI: https://doi.org/10.1007/978-3-319-13761-2_27

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13760-5

  • Online ISBN: 978-3-319-13761-2

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