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How Noncoding RNAs Contribute to Macrophage Polarization

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MicroRNAs and Other Non-Coding RNAs in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Macrophages are an essential component of the innate immune response and adaptive immunity. These cells display a great deal of phenotypic plasticity in order to fulfill their diverse functions. The functional phenotypes of macrophage have been conceptually divided into two classes, namely the M1 and the M2 subtypes. The regulation of macrophage polarization has been extensively studied at the transcriptional, epigenetic, and translational levels and many critical protein mediators have been identified to take part in this cellular event. However, recent evidence indicates that a new type of molecule, noncoding RNAs (ncRNAs), plays a similarly important role in the differential activation of macrophages. This chapter includes a concise summary of the characterization and core protein mediators of macrophage polarization. Furthermore, it reviews in detail the biology of ncRNAs, including miRNAs and lncRNAs, and how they can participate in this process.

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Acknowledgment

This work was supported by NIH grants HL114470, HL105473, and HL076206.

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  1. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Huachun Cui & Gang Liu

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  1. Huachun Cui
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Correspondence to Gang Liu .

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  1. Respiratory Research, Department of Medicine, Royal College of Surgeon in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

    Catherine M. Greene

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Cui, H., Liu, G. (2015). How Noncoding RNAs Contribute to Macrophage Polarization. In: Greene, C. (eds) MicroRNAs and Other Non-Coding RNAs in Inflammation. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-13689-9_4

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