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Peroral Endoscopic Myotomy

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Achalasia
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Abstract

The treatment of achalasia is centered on reducing the resting tone of the lower esophageal sphincter, so that ingested material may pass into the stomach unimpeded.

Multiple treatment modalities have been implemented to accomplish this goal, however the surgical myotomy (Heller) where the longitudinal and circular muscle fibers are divided with sparing the esophageal mucosa has produced the most promising long-term results. In an effort to minimize or eliminate incisions altogether, there has been a strong interest in conducting this myotomy using an endoscopic approach. Recently, the peroral endoscopic myotomy (POEM) has been described in which the circular muscle of the lower esophageal sphincter is divided, while the longitudinal muscle layer is left intact. Early data is promising and suggests that POEM has the potential to provide the efficacy of surgery with the cost and morbidity of a pure endoscopic procedure.

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References

  1. Ortega JA, Madureri V, Perez L. Endoscopic myotomy in the treatment of achalasia. Gastrointest Endosc. 1980;26:8–10.

    Article  CAS  PubMed  Google Scholar 

  2. Rajan E, Gostout CJ, Feitoza AB, Leontovich ON, Herman LJ, Burgart LJ, Chung S, Cotton PB, Hawes RH, Kalloo AN, Kantsevoy SV, Pasricha PJ. Widespread EMR: a new technique for removal of large areas of mucosa. Gastrointest Endosc. 2004;60(4):623–7.

    Article  PubMed  Google Scholar 

  3. Inoue H, Minami H, Kobayashi Y, Sato Y, Kaga M, Suzuke M, Satodate H, Odaka N, Itoh H, Kudo S. Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 2010;42(4):265–71.

    Article  CAS  PubMed  Google Scholar 

  4. Sharata AM, Dunst CM, Pescarus R, Shlomovitz E, Wille AJT, Reavis KM, Swanstrom LL. Peroral endoscopic myotomy (POEM) for esophageal primary motility disorders: analysis of 100 consecutive patients. J Gastrointest Surg. 2015;19:161–70.

    Article  PubMed  Google Scholar 

  5. Familiari P, Giovanni G, Marchese M, Boskoski I, Tringali A, Perri V, Costamagna G. Peroral Endoscopic myotomy for esophageal achalasia: outcomes of the first 100 patients with short-term follow-up. Ann Surg. 2014;00:1–6.

    Article  Google Scholar 

  6. Minami H, Isomoto H, Yamaguchi N, Ohnita K, Takeshima F, Inoue H, Nakao K. Peroral endoscopic myotomy for diffuse esophageal spasm. Endoscopy. 2014;46(Suppl 1E):79–81.

    Google Scholar 

  7. Khashab MA, Messallam A, Onimaru M, Teitelbaum E, Ujiki MB, Gitelis M, Modayil RJ, Hungness ES, Stavropoulos SN, El Zein MH, Shiwaku H, Kunda R, Repici A, Minami H, Chiu P, Ponsky J, Kumbhari V, Saxena P, Maydo A, Inoue H. International multicenter experience with peroral endoscopic myotomy for the treatment of spastic esophageal disorders refractory to medical therapy. Gastrointest Endosc. 2015;1:1–8.

    Google Scholar 

  8. Eckhardt VF. Clinical presentations and complications of achalasia. Gastrointest Surg. 2003;7:595–8.

    Article  Google Scholar 

  9. Starvropoulos SN, Modayil RJ, Friedel D, Savides T. The international per oral endoscopic myotomy survey (IPOEMS): a snapshot of the global POEM experience. Surg Endosc. 2013;27(9):3322–38.

    Article  Google Scholar 

  10. Von Renteln D, Fuchs KH, Fockens P, Bauerfeind P, Vassiliou MC, Werner YB, Fried G, Breithaupt W, Heinrich H, Bredenoord AJ, Kersten JF, Verlaan T, Trevisonno M, Rosch T. Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study. Gastroenterology. 2013;145(2):309–11.

    Article  Google Scholar 

  11. Teitelbaum EN, Soper NJ, Hungness ES. Peroral esophageal myotomy (POEM) and subsequent salvage laparoscopic heller myotomy. Gastroenterology. 2012;142:S1031–2.

    Article  Google Scholar 

  12. Vigneswaran Y, Yetasook AK, Zhao JC, Denham W, Linn JG, Ujiki MB. Peroral endoscopic myotomy (POEM): feasible as reoperation following heller myotomy. J Gastrointest Surg. 2014;18:1071–6.

    Article  PubMed  Google Scholar 

  13. Ujiki MB, Yetasook AK, Zapf M, Linn JG, Carbray JM, Denham W. Peroral endoscopic myotomy: a short term comparison with the standard laparoscopic approach. Surgery. 2013;154(4):893–900.

    Article  PubMed  Google Scholar 

  14. Vigneswaran Y, Ryota T, Gitelis M, Carbray J, Ujiki MB. Quality of life assessment after endoscopic myotomy. Surg Endosc. 2015;29(5):1198–202.

    Article  PubMed  Google Scholar 

  15. Hungness ES, Teitelbaum EN, Santos BF, Arafat FO, Pandolfino JE, Kahrilas PJ, Soper NJ. Comparison of perioperative outcomes between peroral esophageal myotomy (POEM) and laparoscopic Heller myotomy. J Gastrointest Surg. 2013;17:228–35.

    Article  PubMed  Google Scholar 

  16. Kurian AA, Dunst CM, Sharata A, Bhayani NH, Reavis KM, Swanstrom LL. Peroral endoscopic esophageal myotomy: defining the learning curve. Gastrointest Endosc. 2013;77:719–25.

    Article  PubMed  Google Scholar 

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Correspondence to Michael B. Ujiki .

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© 2016 Springer International Publishing Switzerland

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Ward, M.A., Ujiki, M.B. (2016). Peroral Endoscopic Myotomy. In: Fisichella, P., Herbella, F., Patti, M. (eds) Achalasia. Springer, Cham. https://doi.org/10.1007/978-3-319-13569-4_7

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  • DOI: https://doi.org/10.1007/978-3-319-13569-4_7

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13568-7

  • Online ISBN: 978-3-319-13569-4

  • eBook Packages: MedicineMedicine (R0)

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