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The presented work in this book is the on-going research and development towards the transformation of old residential homes to smart homes. The need for transformation is to monitor the well-being conditions of an elderly person living alone in their home. Significant outcomes have been achieved in developing an integrated health informatics framework for long term monitoring of an elderly person living independently. The wireless sensing systems were indigenously designed and developed at the Smart Sensing and Intelligent System research group of Massey University, New Zealand. Novel artificial intelligent methods have been devised to determine the wellness of an elderly person living alone. The deployed sensor systems at the home of an elderly person do not require any direct contact with the inhabitant. The ubiquitous computing environment allows the elderly person to stay as they normally do while providing the monitoring system to be able to recognize their daily activities, and assess and determine the behavior of the elderly person as regular or not.