Biomimetic Scaffolds for Craniofacial Bone Tissue Engineering: Understanding the Role of the Periosteum in Regeneration

  • Michael E. Frohbergh
  • Peter I. LelkesEmail author
Part of the Mechanical Engineering Series book series (MES)


The role of the periosteum in bone tissue engineering is a new and exciting development. Although its regenerative capacity is known and its role in initiating wound healing is well-documented, a complete understanding of the underlying mechanisms and specific cues that cause healing induction is still unknown. Recently, a number of different studies have begun to explore how stimulating periosteal recruitment is involved in regeneration. In this chapter we review the importance of the periosteum as well as a number of different materials used to activate and initiate the healing process indicative of the periosteum. Our own work has focused on using electrospun chitosan/hydroxyapatite composite scaffolds in order to integrate the native periosteal tissue with our material and instigate the healing process in critical size calvarial bone defects. Critical size defects remain elusive and problematic in the clinic to date and tissue engineering is a promising candidate to alleviate such problems. In this chapter we will briefly review our material and its ability to induce osseointegration, osteoinduction and support the formation of new, mineralized tissue in a murine model. This material, along with others, reflect promising and auspicious developments in musculoskeletal tissue engineering and are helping to pave the way in understanding how the periosteum is involved in wound healing.


Osteogenic Differentiation Ultrahigh Molecular Weight Polyethylene Bone Tissue Engineering Composite Scaffold Osteoprogenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported in part by a grant from the National Science Foundation [grant # 0434108]. We are grateful to Dr. Gözde Senel for her help with the SEM, and Dr. Darwin Prokop from the Institute of Regenerative Medicine at Texas A&M University for his generous gift of the mMSCs used in our work. PIL is the Laura H. Carnell Professor of Bioegineering, College of Engineering, Temple University.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Icahn School of Medicine at Mt. SinaiNew YorkUSA
  2. 2.Department of Bioengineering, College of EngineeringTemple UniversityPhiladelphiaUSA

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