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Alveolar Augmentation: Focus on Growth Factors (BMPs)

  • Ulf M. E. WikesjöEmail author
  • Cristiano Susin
  • Jaebum Lee
Chapter
Part of the Mechanical Engineering Series book series (MES)

Abstract

Surgical placement of dental implants is governed by the prosthetic design and the morphology and quality of the alveolar bone. Often, implant placement may be difficult, if at all possible, due to alveolar ridge aberrations. In consequence, prosthetically dictated implant positioning commonly entails bone augmentation procedures. We herein discuss the unique biologic potential, the clinical relevance, and perspectives of bone morphogenetic protein (BMP) technologies (focus on rhBMP-2) for alveolar bone augmentation. We also address merits and short-comings of current treatment protocol including bone biomaterials and guided bone regeneration (GBR). In perspective, our studies suggest that BMPs have an unparalleled, dose-dependent potential to augment alveolar bone and in turn support dental implant fixation and functional loading. Inclusion of BMPs for alveolar augmentation to facilitate dental implant fixation may thus not only enhance predictability of existing clinical protocol but radically change current treatment paradigms making conventional “grafting” and GBR procedures altogether obsolete.

Keywords

Maxillary Sinus Dental Implant Calcium Phosphate Cement Alveolar Ridge Autogenous Bone Graft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Earlier versions of this text have been published for reviews in journals and book chapters. The text is continuously subject to revisions and updating as new information becomes available in our laboratory. Studies elaborated herein conducted in our laboratories were supported by WL Gore and Associates, Genetics Institute, Wyeth Research, Medtronic, Daewoong Pharmaceuticals and Nobel Biocare.

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Further Reading

  1. Fiorini T, Susin C, Lee J, Wikesjö UME (2011) Animal models for alveolar bone augmentation (Chapter 9). In: Ballo A (ed) Implant dentistry research guide: basic, translation and clinical research. Nova Publishers, Hauppauge, NYGoogle Scholar
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  3. Lee J, Fiorini T, Wikesjö UME, Susin C (2011) Animal models for sinus augmentation (Chapter 10). In: Ballo A (ed) Implant dentistry research guide: basic, translation and clinical research. Nova Publishers, Hauppauge, NYGoogle Scholar
  4. Moreno de Freitas R, Spin-Neto R, Violin Dias Pereira LA, Marcantonio Junior E, Wikesjö UME, Susin C (2013) Alveolar ridge and maxillary sinus augmentation using rhBMP-2: systematic review. Clin Implant Dent Relat ResGoogle Scholar
  5. Wozney JM, Wikesjö UME (2008) rhBMP-2: biology and applications in oral and maxillofacial surgery and periodontics. In: Lynch SE, Wisner-Lynch LA, Nevins M, Marx RE (eds) Tissue engineering: applications in oral and maxillofacial surgery and periodontics, 2nd edn. Quintessence Publishing Company, Chicago, pp 159–177Google Scholar
  6. Wikesjö UME, Polimeni G, Qahash M (2005) Tissue engineering with recombinant human bone morphogenetic protein-2 for alveolar augmentation and oral implant osseointegration: experimental observations and clinical perspectives. Clin Implant Dent Relat Res 7:112–119CrossRefGoogle Scholar
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  9. Wikesjö UME, Qahash M, Huang Y-H, Xiropaidis AV, Polimeni G, Susin C (2009b) Bone morphogenetic proteins for periodontal and alveolar indications; biological observations—clinical implications. Orthod Craniofac Res 12:263–270CrossRefGoogle Scholar
  10. Wikesjö UME, Lee J, Susin C (2010) Bone, bone morphogenetic protein-2, implant dentistry: focused review. In: Gottlander R, van Steenberghe D (eds) Proceedings of the First P-I Brånemark Scientific Symposium, Gothenburg 2009. Osseointegration and related treatment modalities: future perspectives, quality of life, and treatment simplification. Quintessence Publishing Company, Chicago, pp 61–71Google Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Ulf M. E. Wikesjö
    • 1
    • 2
    Email author
  • Cristiano Susin
    • 1
    • 2
    • 3
  • Jaebum Lee
    • 1
    • 4
  1. 1.Laboratory for Applied Periodontal & Craniofacial Regeneration (LAPCR)College of Dental Medicine, Georgia Regents UniversityAugustaUSA
  2. 2.Departments of Periodontics and Oral BiologyCollege of Dental Medicine, Georgia Regents UniversityAugustaUSA
  3. 3.Center for Clinical and Translational Craniofacial Research (CCTCR)College of Dental MedicineAugustaUSA
  4. 4.Department of PeriodonticsCollege of Dental Medicine, Georgia Regents UniversityAugustaUSA

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