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Stem Cells Derived Insulin-Secreting Cells for Insulin-Dependent Diabetes Mellitus: Exploiting Laboratory Discoveries

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Obesity and Diabetes

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Abstract

The incidence of childhood diabetes—insulin-dependent diabetes (IDDM) continues to rise steadily, and the ever-increasing push toward more intensive management is limited by rising costs and the unremitting demand this form of therapy places on its recipients. Long-term management requires a multidisciplinary approach that includes physicians, nurses, dietitians, and selected specialists. Lack of care can be lethal and administration of insulin is essential for survival for IDDM patients. Since the identification of the autoimmune etiology of IDDM immunosuppressive agents has been proposed as a preventive treatment against the development of the disease, its nephrotoxicity and other adverse effects make it highly inappropriate for long-term use. While pancreas transplantation and islet cell transplantations also have their own limitations. Cell-based therapies mainly including insulin-secreting cells (ISC) represent a promising approach for treatment of IDDM. ISC can provide an abundant and reproducible source of beta-like cells material for transplantation. A number of highly differentiated ISC have been generated from stem cells which can produce remarkable amount of insulin and release it in response to physiological insulin secretagogues.

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Abbreviations

AD-MSC:

Adipose tissue-derived MSC

ADSC:

Adipose-derived stromal cells

BM:

Bone marrow

EMT:

Epithelial–mesenchymal transition

ESC:

Embryonic stem cell

GAD:

Glutamic acid decarboxylase

GFP:

Green fluorescent protein

h-ASC:

Human adipose-derived stem cells

HbA1c:

Glycosylated hemoglobin

HGF:

Hepatocyte growth factor

HSC:

Hematopoietic stem cells

ICA:

Islet-like cell aggregates

IDDM:

Insulin-dependent diabetes mellitus

IPADSC:

Insulin-producing ADSC

ISC:

Insulin-secreting cells

MSC:

Mesenchymal stem cells

NOD:

Non-obese diabetic

PU-PVP-IPN:

Polyurethane-poly vinyl pyrrolidone-interpenetrating network

SCF:

Stem cell factor

SCID:

Severe combined immunodeficiency

Tregs:

Regulatory T-cells

UCB:

Umbilical cord blood

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Acknowledgment

I am thankful of Dr. Vivek Kute for helping me in literature survey and reviewing the article.

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  1. Stem Cell Laboratory, Department of Transplantation Biology, Stem Cells and Regenerative Medicine and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC), Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad, 380016, Gujarat, India

    Shruti Dave

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  1. Gastroenterology Department, University of Sao Paulo, Hospital das Clinicas, Sao Paulo, SĂŁo Paulo, Brazil

    Joel Faintuch

  2. Radiology Department, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

    SalomĂŁo Faintuch

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Dave, S. (2015). Stem Cells Derived Insulin-Secreting Cells for Insulin-Dependent Diabetes Mellitus: Exploiting Laboratory Discoveries. In: Faintuch, J., Faintuch, S. (eds) Obesity and Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-319-13126-9_14

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  • DOI: https://doi.org/10.1007/978-3-319-13126-9_14

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  • Online ISBN: 978-3-319-13126-9

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