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Cytokine inhibitors

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Biologics for the Treatment of Rheumatoid Arthritis

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Abstract

Tumor necrosis factor (TNF; formerly designated TNF-α) is a cytokine of central importance in multiple inflammatory processes. Its initial discovery was in the field of oncological research, where in the early 1980s it was established as the mediator of tumor-related cachexia (and because of this it was also named ‘cachectin’) and in separate lines of research it was shown to be capable of inducing necrosis of malignant cells in vitro, giving it its current name. While its role in tumor surveillance and antitumor immunity remains of interest – and TNF is in fact approved as a treatment for certain sarcomas – the role of TNF in immunity attracted increasing interest and led to dramatic therapeutic developments.

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  1. Unit for Clinical Therapy Research, Karolinska University Hospital, Stockholm, Sweden

    Ronald F. van Vollenhoven

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van Vollenhoven, R.F. (2016). Cytokine inhibitors. In: Biologics for the Treatment of Rheumatoid Arthritis. Adis, Cham. https://doi.org/10.1007/978-3-319-13108-5_4

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