Optical Urea Rebound Estimation during Dialysis
The aim of the study was to explore the connection of urea rebound and the difference between spKt/V and eKt/V and also the possibility of utilizing UV-absorbance measurements to assess urea rebound. Ten patients of chronic three-times-a-week hemodialysis (HD) were studied. On-line UV-absorbance of spent dialysate was monitored. Single-pool Kt/V (spKt/V), equilibrated Kt/V (eKt/V) and the percentage difference between spKt/V and eKt/V (ΔKt/V) were calculated. Urea rebound was calculated based on urea concentration in blood (Rb) and UV-absorbance in spent dialysate (Ra). ΔKt/V and Rb were not statistically different. Also, Ra and Rb were not statistically different. In summary, the results show that it is possible to assess post-dialysis urea rebound in blood based on UV-absorbance in spent dialysate, which may offer the opportunity to estimate the true dialysis dose and a more personalized approach to the dialysis treatment.
Keywordshemodialysis monitoring rebound Kt/V urea UV-absorption
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