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Mechanistic Modelling Investigates the Neural Basis behind the Hemodynamic Response in fMRI

  • K. Lundengård
  • G. Cedersund
  • F. Elinder
  • M. Engström
Part of the IFMBE Proceedings book series (IFMBE, volume 48)

Abstract

This work serves as a basis for a new type of fMRI analysis, which is based on a mechanistic interpretation of the hemodynamic response to synaptic activity. Activation was measured in the visual cortex of 12 healthy controls and ordinary differential equation models were fitted to the time series of the hemodynamic response. This allowed us to reject or refine previously proposed mechanistic hypotheses. This is the first attempt to describe the hemodynamic response quantitatively based on recent neurobiological findings. This mechanistic approach stands in contrast to the standard phenomenological description using the gamma variate function.

Keywords

functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) response mechanistic modeling ordinary differential equations (ODE) neurovascular coupling 

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • K. Lundengård
    • 1
    • 2
  • G. Cedersund
    • 3
    • 4
  • F. Elinder
    • 3
  • M. Engström
    • 1
    • 2
  1. 1.Division of Radiological Sciences, Department of Medicine and Health SciencesLinköping UniversityLinköpingSweden
  2. 2.Center for Medical Image Science and Visualization (CMIV)Linköping UniversityLinköpingSweden
  3. 3.Department of Clinical and Experimental MedicineLinköping UniversityLinköpingSweden
  4. 4.Department of Biomedical EngineeringLinköping UniversityLinköpingSweden

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