Skip to main content

Herbal and Complementary Medicines Used for Women’s Health

  • Chapter
  • First Online:
  • 1214 Accesses

Abstract

Recent data suggest that the global herbal medicines market continues to increase, with estimates of annual sales as high as $160 B USD. In the United States alone, almost 30 % of U.S. adults use herbal medicines, and of the $11.5 billion spent annually on dietary supplements in the U.S., over half a billion dollars are spent on herbal products. Women continue to be the primary users of herbal supplements, and the use of these products to treat or prevent a wide array of ailments including the menopause, common cold, depression, and other non-life threatening medical conditions is on the rise. In terms of herbal medicines used by women, black cohosh, cranberry, dang gui, green tea, and ginseng are the most common worldwide. While the clinical data for efficacy are often equivocal for most herbal products with the exception of St. John’s wort, there are contraindications, drug interactions and some serious adverse events associated with the use of these products. Where no clinical efficacy has been proven but serious adverse events have been reported, the safety risk in negative (no benefit and potential safety risk), and thus such products should not be recommended.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Anon (2000) Green tea. Altern Med Rev 5(4):372–375

    Google Scholar 

  • Anon (2009) USP revises admission criteria and safety classification for dietary supplements. http://www.usp.org/USPNF/notices/USPRevisedAdmissionCriteria.html. Posted: 10 Apr 2009

  • Anon (2013) The guardian Nigeria, Herbal medicine market hits $160 billion globally. Guardian Mobile

    Google Scholar 

  • Aston JL, Lodolce AE, Shapiro NL (2006) Interaction between warfarin and cranberry juice. Pharmacotherapy 26(9):1314–1319

    Article  CAS  PubMed  Google Scholar 

  • ATGA (2006) Australian Therapeutic Goods Administration Statement. New labeling and consumer information for medicines containing black cohosh (Cimicifuga racemosa). http://www.tga.gov.au/cm/0705blkcohosh.htm. Accessed 10 Aug 2006

  • Awang D (2003) What’s in the name of Panax are those other “Ginsengs”? HerbalGram 57:35–40

    Google Scholar 

  • Beer AM, Osmers R, Schnitker J et al (2013) Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms – comments on major statements of the Cochrane Collaboration report 2012 “black cohosh (Cimicifuga spp.) for menopausal symptoms (review)”. Gynecol Endocrinol 29(12):1022–1025

    Article  PubMed  Google Scholar 

  • Brown MD (1999) Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer. Altern Med Rev 4(5):360–370

    CAS  PubMed  Google Scholar 

  • Council of Responsible Nutrition (CRN) (2013) Consumer survey on dietary supplements. CRN.org

    Google Scholar 

  • Daniels S (2013) CRN survey: 85 % of US adults confident in the safety, quality and effectiveness of dietary supplements. Nutraingredients (Nutraingredients-use.com), 23 Sept 2013

    Google Scholar 

  • European Medicines Agency (EMEA) (2009) Draft assessment report on Cimicifuga racemosa (L.) Nutt., rhizome. Doc. Ref.: EMEA/HMPC/3968/2008. http://www.ema.europa.eu/pdfs/human/hmpc/cimicifugae_rhizoma/396808en.pdf. September 2009

  • Forgo I, Kayasseh L, Staub JJ (1981) Effect of a standardized ginseng extract on general well-being, reaction capacity, pulmonary function and gonadal hormones. Med Welt 19:751–756

    Google Scholar 

  • Fu YF, Xia YK, Shi YP (1998) Treatment of 34 cases of infertility due to tubal occlusion with compound ganggui injection by irrigation. Jiangsu Zhongyi 9:15–16

    Google Scholar 

  • Gao YM, Zhang HK, Duan ZX (1988) Treatment of 112 cases of dysmenorrhea with Danggui jingyou pill. Lanzhou Daxue Xuebao 1:36–38

    Google Scholar 

  • Gardiner P, Graham R, Legedza AT et al (2007) Factors associated with herbal therapy use by adults in the United States. Altern Ther Health Med 13(2):22–29

    PubMed  Google Scholar 

  • Goodin MG, Bray BJ, Rosengreen RJ (2006) Sex- and strain dependent effects of epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) in the mouse. Food Chem Toxicol 44:1496–1504

    Article  CAS  PubMed  Google Scholar 

  • Grant P (2004) Warfarin and cranberry juice: an interaction? J Heart Valve Dis 13(1):25–26

    PubMed  Google Scholar 

  • Griffiths AP, Beddall A, Pegler S (2008) Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 128(6):324–326

    Article  CAS  PubMed  Google Scholar 

  • Guzman G, Kallwitz ER, Wojewoda C et al (2009) Liver injury with features mimicking autoimmune hepatitis following the use of black cohosh. Case Report Med 2009:918156

    Google Scholar 

  • Haber SL, Cauthon KA, Raney EC (2012) Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 27(1):58–65

    Article  PubMed  Google Scholar 

  • Haines CJ, Lam PM, Chung TK et al (2008) A randomized, double-blind, placebo-controlled study of the effect of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) on menopausal symptoms in Hong Kong Chinese women. Climacteric 11(3):244–251

    Article  CAS  PubMed  Google Scholar 

  • Hamann GL, Campbell JD, George CM (2011) Warfarin-cranberry juice interaction. Ann Pharmacother 45(3):e17

    Article  PubMed  Google Scholar 

  • Heitmann K, Nordeng H, Holst L (2013) Pregnancy outcome after use of cranberry in pregnancy–the Norwegian Mother and Child Cohort Study. BMC Complement Altern Med 13:345

    Article  PubMed Central  PubMed  Google Scholar 

  • Herbal Medicinal Products Committee (HMPC) (2007) Assessment of case reports connected to herbal medicinal products containing Cimicifuga racemosa rhizome (black cohosh, root). http://www.emea.europa.eu/pdfs/human/hmpc/26925806en.pdf. Accessed March 2014

  • Hirata JD, Swiersz LM, Zell B et al (1997) Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 68:981–986

    Article  CAS  PubMed  Google Scholar 

  • Hu SY (1976) The genus Panax (ginseng) in Chinese medicine. Econ Bot 30:11–28

    Article  Google Scholar 

  • Huang Y, Nikolic D, Pendland S et al (2009) Effects of cranberry extracts and ursolic acid derivatives on P-fimbriated Escherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-kappa-beta transcriptional response in vitro. Pharm Biol 47(1):18–25

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Isele H (2004) Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid? MMW Fortschr Med 146(11):13

    PubMed  Google Scholar 

  • Jepson RG, Craig JC (2008) Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 1, CD001321

    PubMed  Google Scholar 

  • Jepson RG, Williams G, Craig JC (2012) Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 10, CD001321

    PubMed  Google Scholar 

  • Jepson R, Craig J, Williams G (2013) Cranberry products and prevention of urinary tract infections. JAMA 310(13):1395–1396

    Article  CAS  PubMed  Google Scholar 

  • Jimenez-Saenz M, Martinez-Sanchez C (2007) Green tea extracts and acute liver failure: the need for caution in their use and diagnostic assessment. Liver Transpl 13:1067

    Article  PubMed  Google Scholar 

  • Jordan SA, Cunningham DG, Marles RJ (2010) Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment. Toxicol Appl Pharmacol 243(2):198–216

    Article  CAS  PubMed  Google Scholar 

  • Kim HG, Cho JH, Yoo SR et al (2013) Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial. PLoS One 8(4):e61271

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kim Sooi L, Lean Keng S (2013) Herbal medicines: Malaysian women’s knowledge and practice. Evid Based Complement Alternat Med 2013:438139

    Article  PubMed Central  PubMed  Google Scholar 

  • Leach MJ, Moore V (2012) Black cohosh (Cimicifuga spp.) for menopausal symptoms. Cochrane Database Syst Rev 9, CD007244

    PubMed  Google Scholar 

  • Lee SK, Cho HK, Cho SH et al (2001) Occupational asthma and rhinitis caused by multiple herbal agents in a pharmacist. Ann Allergy Asthma Immunol 86(4):469–474

    Article  CAS  PubMed  Google Scholar 

  • Lim TY, Considine A, Quaglia A et al (2013) Subacute liver failure secondary to black cohosh leading to liver transplantation. BMJ Case Rep, bcr2012009325

    Google Scholar 

  • Locklear TD, Perez A, Caceres A, Mahady GB (2013) Women’s health in Central America: the complexity of issues and the need to focus on indigenous healthcare. Curr Women’s Health Rev 9:1573–1584

    Google Scholar 

  • Low Dog T (2005) Menopause: a review of botanical dietary supplements. Am J Med 118(Suppl 12B):98–108

    Article  PubMed  Google Scholar 

  • Low Dog T (2009) The use of botanicals during pregnancy and lactation. Altern Ther Health Med 15(1):54–58

    PubMed  Google Scholar 

  • Lynch M, Blumenthal M (2013) Herbal supplement sales increase 5.5 % in 2012; herbal supplement sales rise for 9th consecutive year; turmeric sales jump 40 % in natural channels. HerbalGram 99:60–65

    Google Scholar 

  • Mahady GB, Fong HHS, Farnsworth NR (2001a) Cranberry. In: Botanical dietary supplements: quality, safety and efficacy. Swets Publishing, Lisse

    Google Scholar 

  • Mahady GB, Fong HHS, Farnsworth NR (2001b) Ginseng. Botanical dietary supplements: quality, safety and efficacy. Swets & Zeitlinger, Lisse

    Google Scholar 

  • Mahady GB, Parrot J, Lee C et al (2003) Botanical dietary supplement use in peri- and postmenopausal women. Menopause 10(1):65–72

    PubMed  Google Scholar 

  • Mahady GB, Doyle BJ, Locklear TD et al (2006) Black cohosh (Actaea racemosa) for the mitigation of menopausal symptoms: recent developments in clinical safety and efficacy. Womens Health 2(5):773–784

    Google Scholar 

  • Mahady GB, Low Dog T, Barrett ML et al (2008) United States Pharmacopeia review of the black cohosh case reports of hepatotoxicity. Menopause 15:628–638

    Article  PubMed  Google Scholar 

  • Mahady G, Low Dog T, Sarma DN, Giancaspro GI et al (2009) Suspected black cohosh hepatotoxicity – causality assessment versus safety signal. Maturitas 64:139–140

    Article  PubMed  Google Scholar 

  • Mahady GB, Low Dog T, Sarma ND et al (2012) Response to Teschke et al. Pharmacoepidemiol Drug Saf 21(3):339–340

    Article  PubMed  Google Scholar 

  • Mazzanti G, Menniti-Ippolito F, Moro PA et al (2009) Hepatotoxicity from green tea: a review of the literature and two unpublished cases. Eur J Clin Pharmacol 65(4):331–341

    Article  PubMed  Google Scholar 

  • Mei QB, Tao JY, Cui B (1991) Advances in the pharmacological studies of radix Angelica sinensis (Oliv.) Diels (Chinese dang gui). Chin Med J 104(9):776–781

    CAS  PubMed  Google Scholar 

  • Mercado-Feliciano M, Cora MC, Witt KL et al (2012) An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents. Toxicol Appl Pharmacol 263(2):138–147

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • MHRA (2006) MHRA action on safety concerns over black cohosh and liver injury. http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON2024116?ssSourceNodeId=663. Accessed June 2014

  • Naranjo CA, Busto U, Sellers EM et al (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30:239–245

    Article  CAS  PubMed  Google Scholar 

  • National Institutes of Health (2007) The use of complementary and alternative medicine in the United States. National Center for Complementary and Alternative Medicine

    Google Scholar 

  • Natural Health Products Directorate (NHPD) (2007) Black cohosh. http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/prodnatur/mono_cohosh-grappes_e.pdf. Accessed March 2014

  • Niklasson A, Andrén L (2006) Interaction between warfarin and cranberry juice. Lakartidningen 103(11):853–854

    PubMed  Google Scholar 

  • Pan JC, Tsai YT, Lai JN et al (2014) The traditional Chinese medicine prescription pattern of patients with primary dysmenorrhea in Taiwan: a large-scale cross sectional survey. J Ethnopharmacol S0378–8741(14):00011-17

    Google Scholar 

  • Pierard S, Coche JC, Lanthier P et al (2009) Severe hepatitis associated with the use of black cohosh: a report of two cases and an advice for caution. Eur J Gastroenterol Hepatol 21:941–945

    Article  PubMed  Google Scholar 

  • Rahman AB, Ahmad Z, Naing L et al (2007) The use of herbal medicines during pregnancy and perinatal mortality in Tumpat District, Kelantan, Malaysia. Southeast Asian J Trop Med Public Health 38(6):1150–1157

    Google Scholar 

  • Reinhold E (1990) Der Einsatz von Ginseng in der Gynäkologie. Natur-und GanzheitsMedizin 4:131–134

    Google Scholar 

  • Rindone JP, Murphy TW (2006) Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 21(3):283–284

    Article  Google Scholar 

  • Sarma DN, Barrett ML, Chavez ML et al (2008) Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Saf 31(6):469–484

    Article  PubMed  Google Scholar 

  • Schultz H (2013a) Herbal supplements sales rose 5.5 % in US in 2102, ABC says. Nutraingredients-usa.com. Accessed 5 Feb 2014

    Google Scholar 

  • Schultz H (2013b) Supplement sales hit $11.5 B in U.S. report says. www.nutraingredients-usa.com/content/view/print/681603. Accessed 14 June 2014

  • Shibata S, Tanaka O, Shoji J, Saito H (1985) Chemistry and pharmacology of Panax. In: Wagner H, Farnsworth NR (eds) Economic and medicinal plants research, vol 1. Academic, London/San Diego/New York, pp 217–284

    Google Scholar 

  • Srinivas NR (2013) Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives. J Pharm Pharm Sci 16(2):289–303

    CAS  PubMed  Google Scholar 

  • Steel A, Adams J, Sibbritt D, Broom A, Frawley J, Gallois C (2014) The influence of complementary and alternative medicine use in pregnancy on labor pain management choices: results from a nationally representative sample of 1,835 women. J Altern Complement Med 20(2):87–97

    Article  PubMed  Google Scholar 

  • Suvarna R, Pirmohamed M, Henderson L (2003) Possible interaction between warfarin and cranberry juice. BMJ 327(7429):1454

    Article  PubMed Central  PubMed  Google Scholar 

  • Teschke R (2010) Black cohosh and suspected hepatotoxicity: inconsistencies, confounding variables, and prospective use of a diagnostic causality algorithm. A critical review. Menopause 17:426–440

    Article  PubMed  Google Scholar 

  • Teschke R, Bahre R, Genthner A et al (2009) Suspected black cohosh hepatotoxicity, challenges and pitfalls of causality assessment. Maturitas 64:110–115

    Article  Google Scholar 

  • Teschke R, Schmidt-Taenzer W, Wolff A (2011) Spontaneous reports of assumed herbal hepatotoxicity by black cohosh: is the liver-unspecific Naranjo scale precise enough to ascertain causality? Pharmacoepidemiol Drug Saf 20:567–582

    Article  PubMed  Google Scholar 

  • Thavanesan N (2011) The putative effects of green tea on body fat: an evaluation of the evidence and a review of the potential mechanisms. Br J Nutr 106(9):1297–1309

    Article  CAS  PubMed  Google Scholar 

  • Tsai HH, Lin HW, Lu YH et al (2013) A review of potential harmful interactions between anticoagulant/antiplatelet agents and Chinese herbal medicines. PLoS One 8(5):e64255

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Upton R (2010) Dong quai. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD (eds) Encyclopedia of dietary supplements, 2nd edn. Informa Healthcare, New York, pp 208–216

    Chapter  Google Scholar 

  • Wang CC, Cheng KF, Lo WM et al (2013) A randomized, double-blind, multiple-dose escalation study of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) for moderate to severe menopausal symptoms and quality of life in postmenopausal women. Menopause 20(2):223–231

    PubMed  Google Scholar 

  • WHO (1999a) Radix ginseng, vol 1, WHO monographs on selected medicinal plants. World Health Organization, Geneva, pp 168–182

    Google Scholar 

  • WHO (1999b) Flos chamomillae, vol 1, WHO monographs on selected medicinal plants. World Health Organization, Geneva, pp 86–94

    Google Scholar 

  • WHO (1999c) Radix valeriana, vol 1, WHO monographs on selected medicinal plants. World Health Organization, Geneva, pp 267–276

    Google Scholar 

  • WHO (2009a) Fructus macrocarponii, vol 4, WHO monographs on selected medicinal plants. World Health Organization, Geneva, pp 149–166

    Google Scholar 

  • WHO (2009b) Fructus agni casti, vol 4, WHO monographs on selected medicinal plants. World Health Organization, Geneva, pp 9–29

    Google Scholar 

  • Wiklund IK, Mattsson LA, Lindgren R et al (1999) Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group. Int J Clin Pharmacol Res 19(3):89–99

    CAS  PubMed  Google Scholar 

  • World Health Organization (WHO) (2013) WHO traditional medicine strategy 2014–2023. WHO, Geneva

    Google Scholar 

  • Wu AH, Spicer D, Stanczyk FZ et al (2012) Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer Prev Res (Phila) 5(3):393–402

    Article  CAS  Google Scholar 

  • Yi SW, Sull JW, Hong JS, Linton JA, Ohrr H (2009) Association between ginseng intake and mortality: Kangwha cohort study. J Altern Complement Med 15(8):921–928

    Article  PubMed  Google Scholar 

  • Yu SM, Ghandour RM, Huang ZJ (2004) Herbal supplement use among US women, 2000. J Am Med Womens Assoc 59(1):17–24

    PubMed  Google Scholar 

  • Yuan CS, Wei G, Dey L et al (2004) Brief communication: ginseng reduces warfarin’s effect in healthy patients: a randomized, controlled Trial. Ann Intern Med 141(1):23–27

    Article  CAS  PubMed  Google Scholar 

  • Zimmerman R, Witte A, Voll RE et al (2010) Coagulation activation and fluid retention associated with the use of black cohosh: a case study. Climacteric 13:187–191

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gail B. Mahady .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Wicks, S.M., Mahady, G.B. (2015). Herbal and Complementary Medicines Used for Women’s Health. In: Harrison-Woolrych, M. (eds) Medicines For Women. Adis, Cham. https://doi.org/10.1007/978-3-319-12406-3_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-12406-3_13

  • Published:

  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-12405-6

  • Online ISBN: 978-3-319-12406-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics