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Optimized Anesthesia During Cystectomy Improves Postoperative Outcome: A Review of the Key Points

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Keys to Successful Orthotopic Bladder Substitution
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Abstract

This chapter reviews the key points to be considered for optimizing anesthesiology during radical cystectomy with urinary diversion aimed at reducing blood loss, lowering the postoperative complication rate, and improving functional results in patients with orthotopic bladder substitution. These goals can be achieved mainly through the use of thoracic epidural analgesia requiring minimal administration of opioids intra- and postoperatively combined with continuous administration of norepinephrine, facilitating restrictive deferred intraoperative fluid management aiming a zero fluid balance.

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References

  1. Wu CL, et al. Efficacy of postoperative patient-controlled and continuous infusion epidural analgesia versus intravenous patient-controlled analgesia with opioids: a meta-analysis. Anesthesiology. 2005;103(5):1079–88.

    Google Scholar 

  2. Ballantyne JC, et al. The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials. Anesth Analg. 1998;86(3):598–612.

    CAS  PubMed  Google Scholar 

  3. Svircevic V, et al. Thoracic epidural anesthesia for cardiac surgery: a randomized trial. Anesthesiology. 2011;114(2):262–70.

    Article  CAS  PubMed  Google Scholar 

  4. Svircevic V, et al. Meta-analysis of thoracic epidural anesthesia versus general anesthesia for cardiac surgery. Anesthesiology. 2011;114(2):271–82.

    Article  CAS  PubMed  Google Scholar 

  5. Holte K, Kehlet H. Epidural anaesthesia and analgesia – effects on surgical stress responses and implications for postoperative nutrition. Clin Nutr. 2002;21(3):199–206.

    Article  CAS  PubMed  Google Scholar 

  6. Carli F, et al. Epidural analgesia enhances functional exercise capacity and health-related quality of life after colonic surgery: results of a randomized trial. Anesthesiology. 2002;97(3):540–9.

    Article  PubMed  Google Scholar 

  7. Lattermann R, et al. Epidural blockade modifies perioperative glucose production without affecting protein catabolism. Anesthesiology. 2002;97(2):374–81.

    Article  CAS  PubMed  Google Scholar 

  8. Cook TM, Counsell D, Wildsmith JA. Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists. Br J Anaesth. 2009;102(2):179–90.

    Article  CAS  PubMed  Google Scholar 

  9. Jouve P, et al. Epidural versus continuous preperitoneal analgesia during fast-track open colorectal surgery: a randomized controlled trial. Anesthesiology. 2013;118(3):622–30.

    Article  PubMed  Google Scholar 

  10. Lee CT, et al. Alvimopan accelerates gastrointestinal recovery after radical cystectomy: a multicenter randomized placebo-controlled trial. Eur Urol. 2014;66(2):265–72.

    Google Scholar 

  11. Brandstrup B, et al. Which goal for fluid therapy during colorectal surgery is followed by the best outcome: near-maximal stroke volume or zero fluid balance? Br J Anaesth. 2012;109(2):191–9.

    Article  CAS  PubMed  Google Scholar 

  12. Brandstrup B, et al. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens. Ann Surg. 2003;238(5):641.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Futier E, et al. Conservative vs restrictive individualized goal-directed fluid replacement strategy in major abdominal surgery: a prospective randomized trial. Arch Surg. 2010;145(12):1193–200.

    Article  PubMed  Google Scholar 

  14. Hiltebrand LB, et al. Hypotension during fluid-restricted abdominal surgery: effects of norepinephrine treatment on regional and microcirculatory blood flow in the intestinal tract. Anesthesiology. 2011;114(3):557–64.

    Article  CAS  PubMed  Google Scholar 

  15. Di Giantomasso D, et al. Increasing renal blood flow: low-dose dopamine or medium-dose norepinephrine. Chest. 2004;125(6):2260–7.

    Article  PubMed  Google Scholar 

  16. Wuethrich PY, et al. Restrictive deferred hydration combined with preemptive norepinephrine infusion during radical cystectomy reduces postoperative complications and hospitalization time: a randomized clinical trial. Anesthesiology. 2014;120(2):365–77.

    Article  CAS  PubMed  Google Scholar 

  17. Wuethrich PY, et al. Intraoperative continuous norepinephrine infusion combined with restrictive deferred hydration significantly reduces the need for blood transfusion in patients undergoing open radical cystectomy: results of a prospective randomised trial. Eur Urol. 2014;66(2):352–60.

    Article  CAS  PubMed  Google Scholar 

  18. Brandstrup B, Svensen C, Engquist A. Hemorrhage and operation cause a contraction of the extracellular space needing replacement – evidence and implications? A systematic review. Surgery. 2006;139(3):419–32.

    Article  PubMed  Google Scholar 

  19. Reithner L, Johansson H, Strouth L. Insensible perspiration during anaesthesia and surgery. Acta Anaesthesiol Scand. 1980;24(5):362–6.

    Article  CAS  PubMed  Google Scholar 

  20. Lobo DN, et al. Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial. Lancet. 2002;359(9320):1812–8.

    Article  PubMed  Google Scholar 

  21. Chappell D, et al. A rational approach to perioperative fluid management. Anesthesiology. 2008;109(4):723–40.

    Article  PubMed  Google Scholar 

  22. Marjanovic G, et al. Impact of different crystalloid volume regimes on intestinal anastomotic stability. Ann Surg. 2009;249(2):181–5.

    Article  PubMed  Google Scholar 

  23. Schnuriger B, et al. Crystalloids after primary colon resection and anastomosis at initial trauma laparotomy: excessive volumes are associated with anastomotic leakage. J Trauma. 2011;70(3):603–10.

    Article  PubMed  Google Scholar 

  24. Jackson R, Reid JA, Thorburn J. Volume preloading is not essential to prevent spinal-induced hypotension at caesarean section. Br J Anaesth. 1995;75(3):262–5.

    Article  CAS  PubMed  Google Scholar 

  25. Stewart RM, et al. Less is more: improved outcomes in surgical patients with conservative fluid administration and central venous catheter monitoring. J Am Coll Surg. 2009;208(5):725–35.

    Google Scholar 

  26. Matot I, et al. Fluid management during video-assisted thoracoscopic surgery for lung resection: a randomized, controlled trial of effects on urinary output and postoperative renal function. J Thorac Cardiovasc Surg. 2013;146(2):461–6.

    Article  PubMed  Google Scholar 

  27. Shaw AD, et al. Major complications, mortality, and resource utilization after open abdominal surgery: 0.9 % saline compared to Plasma-Lyte. Ann Surg. 2012;255(5):821–9.

    Article  PubMed  Google Scholar 

  28. Hahn RG. Volume kinetics for infusion fluids. Anesthesiology. 2010;113(2):470–81.

    Article  PubMed  Google Scholar 

  29. Hahn RG. Fluid therapy in uncontrolled hemorrhage – what experimental models have taught us. Acta Anaesthesiol Scand. 2013;57(1):16–28.

    Article  CAS  PubMed  Google Scholar 

  30. Rasmussen KC, et al. Hydroxyethyl starch reduces coagulation competence and increases blood loss during major surgery: results from a randomized controlled trial. Ann Surg. 2014;259(2):249–54.

    Article  PubMed  Google Scholar 

  31. Kind SL, et al. Is dilutional coagulopathy induced by different colloids reversible by replacement of fibrinogen and factor XIII concentrates? Anesth Analg. 2013;117(5):1063–71.

    Article  CAS  PubMed  Google Scholar 

  32. Morgan TM, et al. The relationship between perioperative blood transfusion and overall mortality in patients undergoing radical cystectomy for bladder cancer. Urol Oncol. 2011;31(6):871–7.

    Google Scholar 

  33. American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology. 2006;105(1):198–208.

    Article  Google Scholar 

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Correspondence to Patrick Y. Wuethrich MD .

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Wuethrich, P.Y. (2015). Optimized Anesthesia During Cystectomy Improves Postoperative Outcome: A Review of the Key Points. In: Studer, U. (eds) Keys to Successful Orthotopic Bladder Substitution. Springer, Cham. https://doi.org/10.1007/978-3-319-12382-0_3

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  • DOI: https://doi.org/10.1007/978-3-319-12382-0_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12381-3

  • Online ISBN: 978-3-319-12382-0

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